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Stevens-Johnson syndrome after terbinafine therapy

, : Stevens-Johnson syndrome after terbinafine therapy. Journal of the American Academy of Dermatology 30(3): 509

A case is reported in a 61-yr-old woman from Germany with onychomycosis who was treated with terbinafine (250 mg/d) for 8 d. Two days after discontinuation of therapy, a macular eruption appeared on the trunk accompanied by fever and erosions of the oral mucosa. The following day the eruption was generalized with erosions and blisters on 5% of the body surface. A biopsy specimen of the eruption showed a perivascular lymphocytic infiltrate beneath an orthokeratotic epidermis. Stevens-Johnson syndrome was diagnosed and the lesions healed after 2 wk of treatment with oral and topical corticosteroids.


PMID: 8113475

DOI: 10.1016/S0190-9622(08)81961-5

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