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The binding of an antisense oligonucleotide to a hairpin structure via triplex formation inhibits chemical and biological reactions


, : The binding of an antisense oligonucleotide to a hairpin structure via triplex formation inhibits chemical and biological reactions. Nucleic Acids Research 21(24): 5616-5622

The binding of a 26-mer antisense oligodeoxynucleotide to a 69-mer DNA hairpin with a 13 base pair stem, bearing an Rsa1 restriction site, was investigated. The 5' part of the 26-mer annealed to a stretch of 6 purines at the bottom of the hairpin. The formation of a 'double-hairpin' complex between the 69-mer and the 26-mer antisense oligopyrimidines was demonstrated. The association was both sequence and pH-dependent.

US$19.90

DOI: 10.1093/nar/21.24.5616


Other references

Marsh, P.; Burns, D.; Girkin, J., 2003: Practical implementation of adaptive optics in multiphoton microscopy. A dedicated two-photon microscope incorporating adaptive-optic correction of specimen-induced aberrations is presented. Wavefront alteration of the scanning laser beam was achieved by use of a micromachined deformable mirror. Post scan head implem...

Sirotkina, O.V.; Zabotina, A.M.; Berkovich, O.A.; Bazhenova, E.A.; Vavilova, T.V.; Shvartsman, A.L., 2009: Genetic variants of platelet ADP receptor P2Y12 associated with changed platelet functional activity and development of cardiovascular diseases. The key role in platelet aggregation is played by the platelet ADP receptor P2Y12, which is the target for antiaggregant drugs, clopidogrel and ticlopidine. At present, only sporadic data on genetic variants of platelet ADP receptor P2Y12 are avai...

Oba N.; Tomita K.; Yamamoto M.; Istidjab M.; Sudradjat A.; Suhanda T., 1984: Geologic significance of granitic fragments found from pumice flow of 1883 eruption at the Krakatau Group, Indonesia. Abstracts of Papers - Regional Congress on Geology, Mineral and Energy Resources of Southeast Asia (GEOSEA) 5: 24

Gombe S.; Oduor Okelo D., 1985: Impairment of gonadal function and epididymal sperm passage following cremaster muscle transection in the goat. Journal of Andrology 6(2 SUPPL): P-141

Sigvaldason, A.; Olafsson, O.; Gislason, T., 1996: Antiasthmatic drugs in Iceland - an epidemiological survey.. The use of antiasthmatic drugs in Iceland has increased considerably during the last 15 years. The aim of this study was to assess in a well-defined epidemiological population the characteristics of those using antiasthmatic drugs; age, gender, sp...

Waddell, D.E.; Goggans, P.M.; Snyder, G.J., 2012: Novel tactile feedback to reduce overt stuttering. Stuttering is generally considered to be a speech disorder that affects ∼1% of the global population. Various forms of speech feedback have been shown to reduce overt stuttered speaking, and in particular, second speech signal through speech fee...

Hartmann, J.T.; Nichols, C.R.; Droz, J.P.; Horwich, A.; Gerl, A.; Fossa, S.D.; Beyer, J.; Pont, J.; Fizazi, K.; Einhorn, L.; Kanz, L.; Bokemeyer, C., 2000: Hematologic disorders associated with primary mediastinal nonseminomatous germ cell tumors. Background. The association between primary germ cell tumors of the mediastinum (the space between the lung pleura that contains the heart and other chest viscera) and hematologic malignancies has been described by retrospective analysis of patien...

Vagner, E.A.; Vecherovskiĭ, I.F.; Firsov, V.D., 1972: Total gastrectomy following stomach burn. Khirurgiia 48(10): 115-116

Montresor, A., 2011: Cure rate is not a valid indicator for assessing drug efficacy and impact of preventive chemotherapy interventions against schistosomiasis and soil-transmitted helminthiasis. Every year in endemic countries, several million individuals are given anthelminthic drugs in the context of preventive chemotherapy programmes for morbidity control of schistosomiasis and soil-transmitted helminthiasis. The capacity to evaluate a...

Moszkowicz, D.; Almairac, F.; Lefevre, J-H., 2012: What you should know before your surgical residency, but were afraid to ask. Journal of Visceral Surgery 148(4): E318-E320