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The binding of an antisense oligonucleotide to a hairpin structure via triplex formation inhibits chemical and biological reactions

, : The binding of an antisense oligonucleotide to a hairpin structure via triplex formation inhibits chemical and biological reactions. Nucleic Acids Research 21(24): 5616-5622

The binding of a 26-mer antisense oligodeoxynucleotide to a 69-mer DNA hairpin with a 13 base pair stem, bearing an Rsa1 restriction site, was investigated. The 5' part of the 26-mer annealed to a stretch of 6 purines at the bottom of the hairpin. The formation of a 'double-hairpin' complex between the 69-mer and the 26-mer antisense oligopyrimidines was demonstrated. The association was both sequence and pH-dependent.


DOI: 10.1093/nar/21.24.5616

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