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Aminosidine plus sodium stibogluconate for the treatment of Indian kala-azar: a randomized dose-finding clinical trial


, : Aminosidine plus sodium stibogluconate for the treatment of Indian kala-azar: a randomized dose-finding clinical trial. Transactions of the Royal Society of Tropical Medicine and Hygiene 89(2): 219-223

This randomized, open sequential design trial was set up to assess the efficacy, tolerability and toxicity of 20 d courses of combined intramuscular aminosidine and sodium stibogluconate at various dosages in patients with newly-diagnosed kala-azar in Bihar, India. Three successive studies of 96 patients each were originally planned with aminosidine administered at 12, 6 and 3 mg/kg/d, respectively. For each aminosidine dosage, patients were randomly assigned to receive sodium stibogluconate at 20, 10 or 5 mg/kg/d of antimony. Ninety-six patients were enrolled and assigned aminosidine 12 mg/kg/d as scheduled. In the subsequent study with aminosidine at 6 mg/kg/d, the trial was interrupted after 40 patients had entered owing to inadequacy of the treatment. With aminosidine 12 mg/kg/d the success rates with sodium stibogluconate at 20, 10 and 5 mg/kg/d were 88%, 71% and 72%, respectively and did not differ significantly. With aminosidine 6 mg/kg/d, 69%, 50% and 46% of patients were cured with the same sodium stibogluconate doses, respectively; again, there was no significant difference between the subgroups. The overall success rate with aminosidine at 12 mg/kg/d (76%) was significantly higher than that with 6 mg/kg/d (55%) (odds ratio = 2.69; 95% confidence interval, 1.11-6.4). Patients improved clinically and the treatments were equally well tolerated. The combination of aminosidine 12 mg/kg/d and sodium stibogluconate 20 mg/kg/d for 20 d appears to be an effective and safe replacement in Bihar for sodium stibogluconate alone for > or = 40 d.

US$19.90

PMID: 7778155

DOI: 10.1016/0035-9203(95)90503-0


Other references

Noda, Y.; Kobayashi, K.; Fujii, T., 1990: The simultaneous application of abrasion and dry ice therapy for ota's nevus. As a treatment for Ota's nevus, abrasion of the skin that was immediately followed by the application of dry ice therapy, in which the exposed dermis was compressed directly with dry ice, achieved results that were considered satisfactory. Th...

Nakayama, N.; Arakawa, K.; Sasaki, S.; Nakamura, I.; Kimura, M.; Tarumoto, Y., 1996: Investigation of function test in beagle dogs with electro-physiological methods. Journal of Toxicological Sciences 21(5): 405

Ball, M.J., 1976: The why, who, what, when, where, how of selecting a health-care consultant. Hospital Topics 54(6): 50-52

Mikkelsen, H.I.; Jensen, H.A.; Wadskov, S.; Sondergaard, J., 1975: Skin and ocular lesions following long-term treatment with practolol (Eraldin). Ugeskrift for Laeger 137(38): 2188-2191

Wing J.M.; Powell G.W., 1967: Effects of energy source on digestibility of cellulose and protein and upon rumen fermentation in dairy cattle. Florida Agricultural Experiment Stations Annual Report :

Tchernigovtzeff C.; Ragage Willigens J., 1968: Determination of inter molt stages in sphaeroma serratum isopoda flabellifera. Archives de Zoologie Experimentale et Generale 109(2): 305-318

Stroescu, V.; Gane, P.; Granici, A.l.; Constantinidi, M., 1976: Experimental research concerning the relations between the central effects of amphetanime and of certain beta-adrenergic blocking agents. Physiologie 13(3): 219-225

Ortega, O.; Rodriguez, I.; Gallar, P.; Carreno, A.; Gutierrez, M.; Oliet, A.; Lozano, L.; Vigil, A., 2002: Should we offer renal replacement therapy to every elderly patient?. Nephrology Dialysis Transplantation 17(Abstracts Supplement 1): 296

Dernouchamps, J.P.; Vaerman, J.P.; Michiels, J.; Masson, P.L., 1977: Immune complexes in the aqueous humor and serum. The aqueous humor and serum of patients with various ocular diseases were analyzed for the occurrence of rheumatoid factor or immune complexes. Rheumatoid factor was detected by its direct agglutinating activity on Ig[immunoglobulin]G-coated parti...

Escribano, M.J., 1978: Study of a fraction antigenically unrelated to the immunoglobulins obtained by immunoadsorption from anti-hapten or anti-protein rabbit sera. A fraction not antigenically related to the immunoglobulins was obtained together with the antibodies by specific immunoadsorption from either anti-dinitrophenyl or rabbit anti-human gamma globulin antisera. This fraction was called in both cases...