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Effect of chronic thyroid hormone treatment on cycling, ovulation, serum reproductive hormones and ovarian LH and prolactin receptors in rats

, : Effect of chronic thyroid hormone treatment on cycling, ovulation, serum reproductive hormones and ovarian LH and prolactin receptors in rats. Endocrine 3(2): 121-127

Hyperthyroidism was induced in rats by daily subcutaneous injections of thyroxine (1 mg/kg body weight) starting on the day of oestrus. Control rats were injected with saline. Treated rats had normal 4-day vaginal cycles for the first 3 cycles after the initiation of treatment, but the 4th cycle had a lengthened oestrus and the rats then showed constant dioestrus. Only 66, 50, 33 and 10% of treated rats ovulated in cycles 1, 2, 3 and 4 respectively.


PMID: 21153148

DOI: 10.1007/BF02990063

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