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Plasmodium falciparum S-adenosylhomocysteine hydrolase. cDNA identification, predicted protein sequence, and expression in Escherichia coli


, : Plasmodium falciparum S-adenosylhomocysteine hydrolase. cDNA identification, predicted protein sequence, and expression in Escherichia coli. Journal of Biological Chemistry 269(23): 16364-16370

Compounds that specifically inhibit S-adenosylhomocysteine hydrolase (SAHH; EC 3.3.1.1) interfere with the proliferation of Plasmodium falciparum but efforts to identify the enzyme directly in parasite extracts have been unsuccessful. Genetic and biochemical evidence is presented for the presence of a gene encoding P. falciparum SAHH. The gene was transcribed as a 2.8 kilobase mRNA in erythrocytic stage parasites.

US$29.90

PMID: 8206944


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