+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Predictability of heterozygosity scores and polymorphism information content values for rat genetic markers

, : Predictability of heterozygosity scores and polymorphism information content values for rat genetic markers. Mammalian Genome 6(8): 512-520

Construction of a genetic linkage map of the laboratory rat, Rattus norvegicus, establishes the rat as a genetic model. Allele sizes were reported for 432 simple sequence length polymorphisms (SSLPs) genotyped in 12 different substrains belonging to nine different inbred strains of rats. However, these nine strains represent only a fraction of the more than 140 inbred strains available. If allele sizes are not known, alternative indices of markers' polymorphism content can be used, such as heterozygosity (H) and polymorphism information content (PIC). Here, we have determined heterozygosity scores and PIC values for all markers of the rat genetic linkage map, and we evaluate the predictability of the heterozygosity and the PIC values. Correlation analysis between the nine inbred strains reported for the rat map and ten "test" strains yielded r = 0.42 and r = 0.44 for heterozygosity and PIC values, respectively. While the correlation of the indices between the two groups of animals is low, these indices do provide a means of predicting whether a genetic marker will be informative in strains where allele sizes are not known.


PMID: 8589519

DOI: 10.1007/bf00356167

Other references

Shiao Tsung Wen; H.D.J.n, 1992: The fractal characteristics of subsurface wireline logs of Tertiary strata in offshore Taiwan; a preliminary study. Petroleum Geology of Taiwan 27: 225-236

Leavitt L.A.; Donovan W.L., 1979: Perceived infant temperament locus of control and maternal physiological response to infant gaze. Maternal physiologic response was used as an index of maternal attention to infant eye contact. Women (36), each of whom had a 3 mo. old infant, were shown 10 s silent images of a 3 mo. old infant on a videotape monitor. In 1 condition the face po...

Bubnis W.A.; Ofner C.M.IIi, 1991: Investigation of the mechanism of heat crosslinking in a proteinaceous material. Pharmaceutical Research (New York) 8(10 SUPPL): S186

Walen, H., 1975: Hans Spreng, 1901-1975, a pioneer of fruit culture and utilization. Grune 103 (52) 11-14

Sujastani, T., 1981: The state of Indonesian marine fishery resource exploitation. Indonesian agricultural research and development journal(1): 13-20

Yokota, Sadaki, 1996: Dense bar of dumb-bell-shaped peroxisomes of monkey kidney is identical with marginal plate and composed of L-alpha-hydroxy acid oxidase. Cell Structure & Function 21(6): 666

Leibovich, S.J.; Ross, R., 1975: The role of the macrophage in wound repair. A study with hydrocortisone and antimacrophage serum. The role of the monocyte/macrophage in wound repair has been investigated by studying the healing process in wounds depleted of this cell and/or its phagocytic activity. Hydrocortisone acetate (0.6 mg/g body weight) administered as a subcutaneous...

Gaser, C.; Volz, H.P.; Kiebel, S.; Riehemann, S.; Sauer, H., 1999: Detecting structural changes in whole brain based on nonlinear deformations-application to schizophrenia research. This paper describes a new method for detecting structural brain differences based on the analysis of deformation fields. Deformations are obtained by an intensity-based nonlinear registration routine that transforms one brain onto another one. We...

Hagen D.R.; Dziuk P.J., 1979: Hetero spermic insemination as a means for detecting the effects of treatment on male fertility. Journal of Animal Science 49(SUPPL 1): 300-301

Lewis, H.P., 1944: A note on an abnormal specimen of Echinocardium cordatum Pennant. Annals and Magazine of Natural History, 11: 70-72