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Proposed protocols for the determination of potential ocular effects of organophosphorus pesticides


, : Proposed protocols for the determination of potential ocular effects of organophosphorus pesticides. Journal of Applied Toxicology 14(2): 131-134

The US Environmental Protection Agency now requires ocular toxicity testing to support the registration of organophosphorus pesticides. As a first step toward guideline development for the conduct of these studies, preliminary protocols for ocular toxicity testing in the non-rodent and rodent are being proposed by the Office of Pesticide Programs. Proposed protocol parameters include determination of animal health status, measurement of plasma, erythrocyte and retinal cholinesterase activities, ocular assessment by routine ophthalmological examination, slit lamp biomicroscopy, fundic observations, tonometry, electroretinography and determination of objective refractivity, pupillary response and tracking. Gross and detailed histopathological examinations of ocular system components would also be conducted. Associated questions and concerns with regard to ocular toxicity testing are presented. The Agency plans to hold a workshop in the near future to discuss issues related to protocol refinement and guideline development.

US$19.90

PMID: 8027508

DOI: 10.1002/jat.2550140215


Other references

Strnad C.F.; Lin W C.; Carchman R.A., 1988: Human t lymphocyte mitogenesis in response to the b oligomer of pertussis toxin involves an influx of extracellular calcium. FASEB Journal 2(6): ABSTRACT 7889

Lim, H-C.; Bae, J-H.; Song, H-R.; Teoh, S.H.; Kim, H-K.; Kum, D-H., 2011: High tibial osteotomy using polycaprolactone-tricalcium phosphate polymer wedge in a micro pig model. Medial open-wedge high tibial osteotomy has been gaining popularity in recent years, but adequate supporting material is required in the osteotomy gap for early weight-bearing and rapid union. The purpose of this study was to investigate whether t...

Carr, D.M., 2005: A team approach to EHR implementation and maintenance. Nursing Management 35 Suppl 5: 15-6, 24

Nishimura, R.; Nagao, K.; Miyayama, H.; Matsuda, M.; Baba, K.; Matsuoka, Y.; Yamashita, H.; Fukuda, M.; Higuchi, A.; Satoh, A.; Mizumoto, T.; Hamamoto, R., 2000: Thymidylate synthase levels as a therapeutic and prognostic predictor in breast cancer. 5-Fluorouracil (5-FU) is a commonly used adjuvant therapeutic drug in treating breast cancer. 5-FU is metabolically converted to 5-fluorouracil-2'-deoxyuridine-5'-monophosphate-(FdUMP) which is believed to inhibit DNA synthesis in neopla...

Anagnostou, K.; Clark, A., 2016: What do we mean by oral tolerance?. Clinical and Experimental Allergy 46(6): 782-784

Veiras C.; Costas E.; Silva M.; Ramos S.; Losada C.; Amenedo M.; Goyanes V.J., 1985: Chronobiology of radiosensibility in clonal cultures of dinoflagellates. Chronobiologia 12(3): 282

Kimura, I., 1990: Intracellular calcium ion mobilization and nicotinic acetylcholine receptor-mediated signal transduction in neuro-skeletal muscle synapse. Intracellular Ca2+ mobilization in neuro-skeletal muscle synapse was studied by measuring Ca2(+)-aequorin luminescence transients (Ca2+ transients). Ca2+ transients were categorized into three groups as follows: (1) The 1st phase of rapid Ca2+ mob...

Howell, L.P.; Tabnak, F.; Tudury, A.J.; Stoodt, G., 2004: Role of Pap Test terminology and age in the detection of carcinoma invasive and carcinoma in situ in medically underserved California women. Our goals were to evaluate Pap Test findings classified by the Bethesda system, and follow up biopsies from participants in the California Breast and Cervical Cancer Control Program (CaBCCCP) for: 1) correlation in the detection of carcinoma in si...

Lee, J-A.; Jang, D-Jin.; Kaang, B-Kiun., 2011: Two major gate-keepers in the self-renewal of neural stem cells: Erk1/2 and PLCgamma1 in FGFR signaling. Neural stem cells are undifferentiated precursor cells that proliferate, self-renew, and give rise to neuronal and glial lineages. Understanding the molecular mechanisms underlying their self-renewal is an important aspect in neural stem cell biol...

Rowińska-Zakrzewska, E.; Misiewicz, J., 2010: Professor Janina Misiewicz. Pneumonologia i Alergologia Polska 77(5): 484-486