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The YXXL signalling motifs of the bovine leukemia virus transmembrane protein are required for in vivo infection and maintenance of high viral loads


, : The YXXL signalling motifs of the bovine leukemia virus transmembrane protein are required for in vivo infection and maintenance of high viral loads. Journal of Virology 69(7): 4137-4141

The bovine leukemia virus (BLV) transmembrane protein (gp30) contains three YXXL motifs at its carboxyterminal end. Two of these motifs have been implicated in vitro in signal transduction pathways from the external to the intracellular compartment. In order to analyze the biological relevance of these motifs in vivo, recombinant BLV proviruses were constructed. A mutation of the tyrosine residue of the second YXXL motif completely destroyed the infectious potential of the virus in sheep. In contrast, the tyrosine of the first motif appeared to be dispensable for infectivity. However, the propagation of the recombinant virus within the animal was greatly impaired (as demonstrated by PCR and enzyme-linked immunosorbent assay). These recombinant BLVs thus exhibit an attenuated phenotype. Altogether, our data demonstrate the importance of the YXXL motifs of the BLV transmembrane protein for in vivo infection and viral propagation.

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PMID: 7769672


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Buck, D.H.mer; Whitacre, M.A.; Thoits, C.F., 1960: Some experiments in the baiting of carp. Experiments were carried out on 225-acre Slocum Lake, 1.4-acre Oxbow Lake, and 4.2-acre Long Lake to test the use of corn for baiting carp (Cyprinus carpio) to a small area where they could be enclosed and killed with rotenone. Sour corn seemed to...

Prod'hon, J.; Bain, O., 1972: Larval development in Anopheles stephensi of Oswaldofilaria bacillaris, filaria of South American caimans and new description of adults. Annales de Parasitologie Humaine et Comparee 47(5): 745-758

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