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The phenylpyrroles: the history of their development at Ciba


, : The phenylpyrroles: the history of their development at Ciba. Seed treatment: progress and prospects: Proceedings of a Symposium held at the University of Kent, Canterbury, 5-7 January 1994: 129-134

Fenpiclonil and fludioxonil are 2 fungicides from phenylpyrrole chemistry that have been developed by Ciba. They are both highly active as seed treatments in a wide range of crops, including wheat and barley. Their development was based on the lead structure pyrrolnitrin, a natural antimycotic. Using the TOSMIC route many 4-phenylpyrroles were synthesized and tested for efficacy. The 2 most active compounds, fenpiclonil and fludioxonil were chosen for further development.

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