geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Zinc, copper, and zinc- or copper-dependent enzymes in human hypertension


, : Zinc, copper, and zinc- or copper-dependent enzymes in human hypertension. Biological Trace Element Research 49(2-3): 97-106

Imbalance of zinc and copper status has been hypothesized in human hypertension. A case-control study was carried out to elucidate the possible relationship between zinc and copper status and essential hypertension. Thirty-one subjects affected by mild stable hypertension, pharmacologically untreated, were investigated together with 31 normotensive controls individually matched for sex, age, and smoking habits. Zinc and copper in serum and urine were measured, and serum activities of alkaline phosphatase (AP), lactic dehydrogenase (LDH), copper-zinc superoxide dismutase (Cu-Zn SOD), lysyl oxidase (LOX), and monoamine oxidase (MAO) were evaluated. No significant difference in serum and urine zinc and copper content as far as in serum activity of zinc (AP and LDH) or copper (Cu-Zn SOD, LOX, and MAO)-dependent enzymes was found between hypertensives and normotensives. Positive relationships were found in normotensives between serum and urine levels of zinc (r = 0.577; p = 0.001) and copper (r = 0.394; p = 0.028), and between serum copper and Cu-Zn SOD (r = 0.534; p = 0.002). In normotensives, diastolic blood pressure and serum zinc were positively related (r = 0.370; p = 0.041). In hypertensives, inverse correlations were observed between diastolic blood pressure and AP (r = -0.498; p = 0.004) and Cu-Zn SOD (r = -0.452; p = 0.011), and between systolic blood pressure and LOX (r = -0.385; p = 0.033). Diastolic blood pressure was related to LDH inversely in hypertensives (r = -0.357; p = 0.049) and positively in normotensives (r = 0.457; p = 0.010). In normotensives diastolic blood pressure was inversely related with MAO (r = -0.360; p = 0.046). These findings support the hypothesis that an imbalance of zinc and copper status might be involved in human hypertension.

US$19.90

PMID: 8562290

DOI: 10.1007/bf02788959


Other references

Lavrukhina A.K., 1991: The nucleosynthesis of the solar system. Geokhimiya 1991(7): 926-935

Sawitz, W.; Odom, W.; Lincicome, D., 1938: Comparative efficiency of the N.l.H. anal swab examination and stool exam'nation by brine and zinc sulphate flotation for Enterobiua infection. Journal of Parasitology Suppl, 246: 9

Iskandarov, A.I., 1993: Toxicometric assessment of pneumonias and acute respiratory failure in poisonings. Sudebno-Meditsinskaya Ekspertiza 36(3): 23-25

Corsino, J.; Bolzani, V.D.S.lva; Pereira, A.M.ria S.; Franca, S.C.stro; Furlan, M., 1998: Further sesquiterpene pyridine alkaloids from Maytenus aquifolium. Two new sesquiterpene evoninate alkaloids, aquifoliunine E-III and aquifoliunine E-IV, were isolated from the root bark of Maytenus aquifolium. The structures of the new compounds were elucidated on the basis of spectroscopic methods, including ES...

Light, I.S.; Zinsser, H.H., 1961: Determination of rate of formation and nucleation time of calcium oxalate in various systems. In the investigation of the role of vitamin B6 deficiency in the formation of calcium oxalate stones in stone-forming patients, a modified Fisher Nefluorophotometer was utilized to measure rates of appearance of precipitates and the nucleation tim...

Mancuso, A., 2010: Hepatocellular carcinoma in thalassemia: A critical review. Due to blood transfusions, thalassemics are often infected with either hepatitis C virus (HCV) or hepatitis B virus and often have hemochromatosis. Hepatocellular carcinoma (HCC) has emerged in thalassemics only recently as a result of the improve...

Dharmatti, P.R.; Patil, R.V.; Bhagvanthgoudar, M.H., 2004: Development of TOLCV resistant hybrids in tomato. A series of experiments were conducted in Karnataka, India, from 1997 to 2000 under irrigated conditions to find high-yielding Tomato leaf curl virus (TOLCV)-resistant tomato hybrids. Heterosis for TOLCV and fruit yield of 50 hybrids of tomato der...

Cope T.C.; Nichols T.R., 1988: Reflex organization among ankle extensors and pretibial flexors in the chronic spinal cat. Society for Neuroscience Abstracts 14(2): 795

Harbeck, N.; Ewer, M.S.; D.L.urentiis, M.; Suter, T.M.; Ewer, S.M., 2011: Cardiovascular complications of conventional and targeted adjuvant breast cancer therapy. Adjuvant therapy has improved the survival of women with early breast cancer (BC). Meta-analyses suggest that anthracycline-based regimens reduced the annual BC death rate by ~4% in women below the age of 5 and 2% in older women. Novel agents desi...

Witting, M.D.; Magder, L.; Heins, A.E.; Mattu, A.; Granja, C.A.; Baumgarten, M., 2006: ED predictors of upper gastrointestinal tract bleeding in patients without hematemesis. In patients with gastrointestinal (GI) tract bleeding, the bleeding source is uncertain in the absence of hematemesis. We sought to identify clinical variables predictive of an upper GI bleeding source. This retrospective cohort study involved pat...