+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effects of physical training on metabolic control in elderly type 2 diabetes mellitus patients

, : Effects of physical training on metabolic control in elderly type 2 diabetes mellitus patients. Clinical Science 93(2): 127-135

1. The specific role of physical activity in the treatment of type 2 diabetes is still subject to discussion. A randomized prospective study was performed, investigating both the influence of physical training on metabolic control and the feasibility of physical training in the elderly. 2. A total of 58 patients (mean age: 62 +/- 5 years; range: 55-75 years) with type 2 diabetes were randomized to either a physical training or a control programme. The training programme consisted of three sessions a week, aiming at 60-80% of the maximal oxygen uptake (VO2max). The 12 week supervised period was followed by a 14 week non-supervised one. The control group followed an educational programme. VO2max was assessed during exercise on a cycle ergometer. Glycosylated haemoglobin (HbA1c) was used as a measure for glucose control, and an insulin tolerance test was performed to test insulin sensitivity. Multivariate analysis of variance, with repeated measures design, was used to test differences between groups. 3. Fifty-one patients completed the study. VO2max was higher in the training group than in the control group both after 6 weeks (P < or = 0.01 between groups) and after 26 weeks [training group: 1796 +/- 419 ml/min (prestudy), 1880 +/- 458 ml/min (6 weeks), 1786 +/- 591 ml/min (26 weeks); control group: 1859 +/- 455 ml/min (prestudy), 1742 +/- 467 ml/min (6 weeks), 1629 +/- 504 ml/min (26 weeks)]. Blood glucose control and insulin sensitivity did not change during the study. Levels of total triacylglycerols, very-low-density lipoprotein-triacylglycerols and apolipoprotein B were significantly lower after 6 weeks (P < or = 0.01, P < or = 0.05, P < or = 0.05 between groups respectively), and so was the level of total cholesterol after 12 weeks of training (P < or = 0.05 between groups). 4. Physical training in obese type 2 diabetic patients over 55 years of age does not change glycaemic control or insulin sensitivity in the short-term. Regular physical activity may lower triacylglycerol and cholesterol levels in this group of patients. 5. Finally, physical training in motivated elderly type 2 diabetic patients without major cardiovascular or musculoskeletal disorders is feasible, but only under supervision.


PMID: 9301427

DOI: 10.1042/cs0930127

Other references

Moore, I.M.Ki.; Miketova, P.; Hockenberry, M.; Krull, K.; Pasvogel, A.; Carey, M.; Kaemingk, K., 2008: Methotrexate-induced alterations in beta-oxidation correlate with cognitive abilities in children with acute lymphoblastic leukemia. Treatment advances, including central nervous system (CNS) treatment with methotrexate, have led to significant gains in disease-free survival from childhood acute lymphoblastic leukemia (ALL). However, methotrexate has been associated with neurol...

Svejcar, T., 1990: Root length, leaf area, and biomass of crested wheatgrass and cheatgrass seedlings. Bromus tectorum and Agropyron desertorum cv. Nordan were grown for 60 d after sowing, with 4 seedlings/pot at max. temp. of 28 degrees C and min. temp. 4 degrees . Plants were watered twice per week. Plants were sampled weekly at 24-60 d after sow...

Andreou, A.Yiangou., 2011: Anomalous origin of the left main coronary artery: course determination by computed tomography. Arquivos Brasileiros de Cardiologia 96(4): 342-342

Kubo, M.; Odani, T.; Nakamura, S.; Tokumaru, S.; Matsuda, H., 1992: Pharmacological study on kefir--a fermented milk product in Caucasus. I. On antitumor activity (1). The antitumor activity of kefir (YK-1), a fermented milk product in Caucasus, was investigated. YK-1 at oral doses of 100 or 500 mg/kg inhibited the proliferation of solid tumor of Ehrlich ascites carcinoma transplanted subcutaneously in mice. YK-...

Hanai, H.; Takeuchi, K.; Iida, T.; Kashiwagi, N.; Saniabadi, A.R.; Matsushita, I.; Sato, Y.; Kasuga, N.; Nakamura, T., 2004: Relationship between fecal calprotectin, intestinal inflammation, and peripheral blood neutrophils in patients with active ulcerative colitis. Active ulcerative colitis (UC) is associated with elevated granulocytes and monocytes/macrophages (GM) which show activation behavior and increased survival time. Further, fecal calprotectin (a stable neutrophil protein) level parallels intestinal...

Chua, E.F.; Schacter, D.L.; Rand-Giovannetti, E.; Sperling, R.A., 2007: Evidence for a specific role of the anterior hippocampal region in successful associative encoding. It has been well established that the hippocampal formation plays a critical role in the formation of memories. However, functional specialization within the hippocampus remains controversial. Using functional magnetic resonance imaging (fMRI) dur...

Anonymous, 1969: Infection and serum-lipids. Lancet 2(7635): 1409-1410

Karkuti, Rt, 1981: Oxidation reduction potential and the nutritive regime of the soil as affected by various methods of rice irrigation. Biulleten' Nauchno tekhnicheskoi informatsii Vsesoiuznyi nauchno issledovatel'skii institut risa: 1) 58-61

Espinel Ingroff, A.; Steele Moore, L., 2001: In vitro activities of voriconazole against the mycelial and yeast forms of Penicillium marneffei by different testing conditions. Mycoses 44(Supplement 1): 17

Wong, R.K.; Boedeker, B.; Hickey, T.M.; Wilkinson, D.S.; Johnson, L.F., 1984: Lithium chloride: protective and antisecretory properties in rats. Lithium chloride was evaluated as a potential protective agent against ethanol-induced hemorrhagic gastritis in rats. Rats received lithium chloride intragastrically (30, 60, or 90 mg/kg i.g.) or subcutaneously (3, 5, 10, 15, 20, 30, 60, or 90 mg/...