geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Human plasma albumin transports [13C]docosahexaenoic acid in two lipid forms to blood cells


, : Human plasma albumin transports [13C]docosahexaenoic acid in two lipid forms to blood cells. Journal of Lipid Research 38(8): 1571-1582

Docosahexaenoic acid (22:6) decreases blood platelet function and is highly concentrated in the brain where its depletion leads to functional impairments. Because the platelets and blood brain barrier capillary endothelium cannot hydrolyze the complex lipids for fatty acid (FA) uptake, nonesterified FA (NEFA) bound to albumin are assumed to be the delivery route of FA to these cells. The supply of 13C-labeled 22:6 to blood cells by plasma albumin was studied in humans after a single ingestion of this FA esterified in a triglyceride (TG). The 22:6 13C/12C ratio, measured by gas chromatography combustion-isotope ratio mass spectrometry was measured in lipid classes from albumin, platelets, leukocytes, and erythrocytes (taken as a tentative index of the brain uptake). Nonesterified (13C)22:6 bound to albumin was rapidly produced after ingestion, as a result of the hydrolysis of very low density lipoprotein (VLDL) plus chylomicron TG. We found that albumin carried another source of 22:6, lyso-phosphatidylcholines (lyso-PC), in which (13C)22:6 accumulated while the nonesterified (13C) 22: 6 reached its minimal plasma concentrations. Computation of the relative contribution of NEFA and lyso-PC for the (13C)22:6 delivery to platelets and erythrocytes showed that the (13C)22:6 supply to platelets occurred uniquely through NEFA, whereas this pool was weakly involved in the delivery to erythrocytes. In contrast, lyso-PC was uniquely concerned with the 22:6 delivery to erythrocytes and represented the major part of this supply. We conclude that plasma albumin carries 22:6 in two lipid forms that are involved differently in the delivery of this FA to target cells.

US$29.90

PMID: 9300779


Other references

Studzińska-Sroka, Eżbieta.; Piotrowska, H.; Kucińska, Młgorzata.; Murias, M.; Bylka, Wława., 2016: Cytotoxic activity of physodic acid and acetone extract from Hypogymnia physodes against breast cancer cell lines. Lichens produce specific secondary metabolites with different biological activity. This study investigated the cytotoxic effects of physodic acid, in addition to the total phenolic content and cytotoxic and antioxidant activity of acetone extract...

Jayaprakash, K.; Madhavan, S.; Kumary, V.Sudha.; Anish, P.G.; George, R., 2015: Benign neoplasms in the right ventricular outflow tract. We describe benign neoplasms in the right ventricular outflow tract in two patients: one, a 2-month-old male with a rhabdomyoma, and the other, a 48-year-old woman with a myxoma. Each of these tumors is rare in that location.

Anonymous, 1978: British aid. A select bibliography. The bibliography is based on the holdings of the Ministry of Overseas Development Library and is intended to provide a guide to the main British publications relating to aid. It includes legislation and technical co-operation agreements with inter...

Lin, S.S.; Chang, D.J.; Chen, M.T.; Chen, C.C., 2002: Wet air oxidation of a direct dye solution catalyzed by CoAlPO4 -5. Performance assessment and kinetic study. Wet air oxidation (WAO) of a prepared direct dye solution was tested by using the CoAIPO4 -5 catalyst. Addition of CoAIPO4 -5 could effectively improve rate of color removal and the activation energy of color removal could decrease from about 110...

Broecker Wallace S., 1987: Greenhouse surprises. Yearbook - Lamont-Doherty Geological Observatory of Columbia University 1987: 11-15

Bowman, RI., 1983: The evolution of song in Darwin's finches. Unknown

Meschia, G.; Wolkoff, A.S.ark; Barron, D.H., 1959: The oxygen, carbon dioxide and hydrogen-ion concentrations in the arterial and uterine venous bloods of pregnant sheep. By means of indwelling plastic catheters, blood samples have been drawn from an artery and one or more uterine veins of unanesthetized pregnant ewes at selected stages in gestation. The oxygen content, pH and plasma CO2 were determined on the samp...

Guan, Y.; Liu, P.; Deng, C.; Ni, M.; Xiong, S.; Lin, C.; Hu, X-Yu.; Ma, J.; Wang, L., 2014: Dynamic self-inclusion behavior of pillar[5]arene-based pseudo[1]rotaxanes. It was found that spontaneous isomerization takes place between three isomers of a pillar[5]arene (P5)-based pseudo[1]rotaxane. The isomerization process could be monitored by (1)H NMR spectra in polar solvent and the geometric configurations of t...

Masaoka, I.; Yakabi, K.; Nakamura, T., 1994: Effect of aging on the secretory function of parietal cells in human. Gastroenterology 106(4 SUPPL ): A130

Anonymous, 1974: Committee charges and appointments 1974/75. Bulletin of the Medical Library Association 62(4): 425-439