+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The effect of level of feed intake on the pharmacokinetic disposition and efficacy of ivermectin in sheep

, : The effect of level of feed intake on the pharmacokinetic disposition and efficacy of ivermectin in sheep. Journal of Veterinary Pharmacology & Therapeutics 19(2): 89-94

The kinetic disposition of orally administered (3H)-Ivermectin (IVM) was examined in sheep in which the feed intake was maintained at either 800 or 400 g/day. The (3H)-metabolites were almost completely associated with particulate digesta in the rumen. In the low feed intake group the digesta flow was slower than in sheep on high feed intake. This resulted in an extended residence time and greater availability of IVM and its metabolites. The anthelmintic efficacy of IVM was then examined in sheep in which feed intake was reduced from 800 g/day to 400 g/36h prior to and 36h after IVM administration. In sheep with reduced intake 97% of IVM-resistant Haemonchus contortus were removed, compared with 53% in sheep maintained on high feed intake.


PMID: 8735414

DOI: 10.1111/j.1365-2885.1996.tb00018.x

Other references

Phondke G.P.; Madyastha K.R.; Madyastha P.R.; Barth R.F., 1981: Quantitative assay for lectin induced cyto agglutination by an electronic particle counting technique. A method employing an electronic particle-counting technique was used to quantify lectin-induced agglutination of human granulocytes and lymphocytes with concanavalin A or wheat germ agglutinin. The number and mean volume of single cells and aggre...

International Society For Developmental Psychobiology, 1997: 29th Annual Meeting of the International Society for Developmental Psychobiology, Washington, DC, USA, November 13-16, 1996. This meeting contains abstracts and posters of 118 papers written in English.

Fink, M.; Freedman, A.M.; Zaks, A.M.; Resnick, R.B., 1971: Narcotic antagonists: another approach to addiction therapy. American Journal of Nursing 71(7): 1359-1363

Panduro Barón, J.G.; Lagos Trujillo, J.; González Hernandez, A.G.; Amézcua Guevara, G., 1994: Cases of hydatidiform mole at the Nuevo Hospital Civil in Guadalajara. Thirty nine patients with hydatiform mole with clinical, echosonographic and hormonal diagnosis, were analyzed, from March, 1991 to February 1993 at the Nuevo Hospital Civil de Guadalajara. Incidence was I out of 301 pregnancies; average age, 24.6...

Hu, X.; Benson, P.J.; Mack, L.M.; Xia, H.; Emerson, E.O.; Ruby, M.A.; Gupta, V.; Zaren, H.A.; Singh, S.V., 1996: Preferential induction of mouse liver glutathione transferase pi by allyl-group containing organosulfur compounds from garlic. Proceedings of the American Association for Cancer Research Annual Meeting 37(0): 271-272

Norlén, L.; Sundin, T., 1982: Influence of the adrenergic nervous system on the lower urinary tract and its clinical implications. The morphology of the adrenergic nervous systems as well as adrenoceptor functions of the human lower urinary tract are outlined and compared to some animal studies. Special emphasis is given to the altered adrenergic innervation and adrenoceptor...

Fleming C.R.; Nelson J., 1988: Nutritional options. Kinney, J M , K N Jeejeebhoy, G L Hill And O E Owen Nutrition And Metabolism in Patient Care Xvi+797p W B Saunders Co : Philadelphia, Pennsylvania, Usa; London, England, Uk Illus 752-772

Ozturk, B., 2002: The Marmara Sea, a link between the Mediterranean and the Black Sea. Unknown

Shaw, S.N.; Bacon, W.L.; Vasilatos-Younken, R.; Nestor, K.E., 1987: Pulsatile secretion pattern of growth hormone in turkeys: effects of age and sex. Male and female turkeys were cannulated through the jugular vein, and blood samples were withdrawn remotely at 10-min intervals for a period of 8 hr at two points in the post-hatch growth phase (4 and 14 weeks of age). Growth hormone (GH) concentr...

Kirschner, M.W.; Schachman, H.K., 1973: Local and gross conformational changes in aspartate transcarbamylase. Biochemistry 12(16): 2997-3004