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Biochemical aspects of N-heterocyclic complex-I inhibitors with insecticidal activity

, : Biochemical aspects of N-heterocyclic complex-I inhibitors with insecticidal activity. Biochemical Society Transactions 27(4): 602-606

The interaction of substituted aminopyrimidines with NADH:ubiquinone oxidoreductase complex I, the molecular target site for new acaricides and insecticides from the pyrazole and aminopyrimidine chemical classes, from Musca domestica flight-muscle mitochondria was studied. Inhibition of membrane-bound and solubilized complex I and other quinone-dependent dehydrogenases was determined to characterize the compounds used in terms of efficiency and quinone-site specificity.


DOI: 10.1042/bst0270602

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