geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effects of in vitro exposure of beluga whale leukocytes to selected organochlorines


, : Effects of in vitro exposure of beluga whale leukocytes to selected organochlorines. Journal of Toxicology and Environmental Health. Part A 55(7): 479-493

The effects of in vitro exposure to different organochlorines were evaluated on immune functions of beluga whale peripheral blood leukocytes and splenocytes. The effects of different concentrations of four different congeners of PCBs (138, 153, 180, and 169) as well as two DDT metabolites (p,p'-DDT and p,p'-DDE) were evaluated on phagocytosis and cell proliferation. The effects of dioxins and mixtures of organochlorines were also evaluated on cell proliferation. The different compounds tested had no marked effect on phagocytosis. PCB 138 and p,p'-DDT, but not PCB 153, PCB 180, PCB 169, and p,p'-DDE, reduced significantly the proliferative response of beluga splenocytes cultured either with or without phytohemagglutinin A (PHA). Proliferation of beluga splenocytes was not markedly affected by exposure to 5 ppm of PCB 138, 153, 180, and 169 separately. Exposure to a mixture of congeners 138, 153, and 180 (5 ppm each) significantly reduced splenocytes proliferation, but not the mixture of congeners 138, 153, 180, and 169 (5 ppm each). TCDD did not affect cell proliferation in our study. The reduced proliferation of beluga cells exposed in vitro to mixtures of organochlorines at concentrations in the range of those observed in tissues of St. Lawrence belugas might provide a basis to support the hypothesis that contaminants induce immunosuppression in these animals.

US$19.90

PMID: 9860322

DOI: 10.1080/009841098158287


Other references

Kunisawa, T.; Nagata, O.; Nomura, M.; Iwasaki, H.; Ozaki, M., 2004: A comparison of the absolute amplitude of motor evoked potentials among groups of patients with various concentrations of nitrous oxide. It has been shown in previous studies that nitrous oxide (N(2)O) suppresses the amplitude of motor evoked potentials (MEPs) in individual subjects. In the present study, we compared the absolute amplitude and latency of MEPs among groups of patien...

Diebler, C.; Ponsot, G., 1983: Hamartomas of the tuber cinereum. The hamartoma of the tuber cinereum, a midline dysraphic syndrome, corresponds to a mass of normal neuronal tissue implanted in the area of the mamillary bodies. It has no evolutionary potential, but association to other cerebral malformations has...

Uppal, S.Saleem.; Naveed, A.Khaliq.; Baig, S.; Chaudhry, B., 2015: Expression of REG Iα gene in type 2 diabetics in Pakistan. The escalating rate of diabetes' has prompted researchers around the world to explore for early markers. A deficit of functional β-cell mass plays a central role in the pathophysiology of type 2 diabetes. The REG (Regenerating) gene, encodin...

Jar, A.M.; Mundo, S.L.; Braun, M., 1993: Cellular immune response in cattle infected with foot-and-mouth disease virus. Veterinary Immunology & Immunopathology 35(SUPPL ): 104

Kirshner, N.; Schanberg, S.M.; Ferris, R.M., 1971: Molecular aspects of the storage and uptake of catecholamines. Advances in Drug Research 6: 121-156

Tomizawa, K.; Sunada, S.; Lu, Y.F.; Oda, Y.; Kinuta, M.; Matsushita, M.; Li, S.T.; Moriwaki, A.; Tsutsui, K.; Saito, T.; Hisanaga, S.; Takei, K.; Matsui, H., 2003: Cdk5-dependent phosphorylation of Amphiphysin I and Dynamin I Potential role in clathrin-mediated endocytosis. Neuroscience Research Supplement (26): S19, 2002( )

Madhavan, A., 2001: Painted bat (Kerivoula picta) - an elusive bat. Bat Net. January; 21: 1pp.

Webb, Robert G., 1950: Range extension of the chicken turtle in Oklahoma. Deirochelys reticularia is recorded from McCurtain, Seminole and Cleveland Counties.

Bamber, S.D.; Naylor, E., 1997: Sites of release of putative sex pheromone and sexual behaviour in female Carcinus maenas. Pre-moult female Carcinus maenas urine was confirmed as a source of putative sex pheromone. The sexual and temporal specificity of bioactivity in pre-moult female urine was demonstrated when urine samples taken from inter-moult and pre-moult male...

Weng, C-Chieh.; Kuo, K-Kai.; Su, H-Ting.; Hsiao, P-Jung.; Chen, Y-Wen.; Wu, D-Chyang.; Hung, W-Chun.; Cheng, K-Hung., 2015: Pancreatic Tumor Progression Associated With CD133 Overexpression: Involvement of Increased TERT Expression and Epidermal Growth Factor Receptor-Dependent Akt Activation. The aim of this study was to investigate the role of CD133 in pancreatic ductal adenocarcinoma malignancy and its involvement in epidermal growth factor receptor (EGFR) signaling. The effects of CD133 overexpression on cell proliferation, migratio...