+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Angiogenic activity of Onchocerca volvulus recombinant proteins similar to vespid venom antigen 5

, : Angiogenic activity of Onchocerca volvulus recombinant proteins similar to vespid venom antigen 5. Molecular and Biochemical Parasitology 109(2): 91-99

Although the mechanisms underlying the host inflammatory response in ocular onchocerciasis have been examined, the role of particular parasite proteins in this process remains largely unexplored. Recently, it was found that one of the most abundant expressed sequence tags in Onchocerca volvulus infective larvae encoded a protein with similarities to a component of vespid venom. This clone was designated O. volvulus Activation associated Secreted Protein -1 (Ov-asp-1). We report the characterization of three members of a family of proteins, designated the Ov-ASP family, of which Ov-ASP-1 is a member. Sequence based and phylogenetic analyses suggest that these proteins form a filarial specific protein family related to both the vespid venom antigen 5 and the vertebrate CRISP/Tpx family of proteins. The three members of the Ov-ASP family exhibit distinct patterns of expression in the life cycle of O. volvulus. Genomic Southern blot analyses indicate that several genes encoding sequences related to the Ov-asp family are present in the genome of O. volvulus. Recombinant proteins expressed from full length cDNAs encoding two members of the Ov-asp family were found to induce an angiogenic response after injection into corneas of naive mice, and vessel formation was associated with only minor inflammatory cell infiltration. These data suggest that Ov-ASP proteins may directly induce an angiogenic response and may therefore contribute to corneal neovascularization in onchocercal keratitis.


PMID: 10960168

DOI: 10.1016/s0166-6851(00)00231-0

Other references

Klots, E.B., 1944: Notes on the Gomphinae (Odonata) with descriptions of new species. American Museum Novitates, no. 1259: 11

Moinuddin, J.F.; Lee, H.W., 1958: Effects of feeding diets containing sucrose, cellobiose or glucose on the dry weights of cleaned gastrointestinal organs in the rat. Compared to feeding basal (67%) cornstarch or 25% glucose or 25% sucrose diets, feeding a 15% cellobiose diet to rats for 4-5 weeks resulted in diarrhea, smaller body weight gains, greater small gut weight relative to body weight, greater absolute...

Staples, A.F., 1965: Ranula Of The Sublingual Salivary Gland. Texas Dental Journal 83: 7-8

Cano-Martínez, J.A.; Nicolás-Serrano, G.; Andrés-Grau, J.; Bento-Gerard, J., 2016: Treatment of distal-third clavicular fractures (Neer type ii-b) with a triple button device. The purpose of this study is to describe the outcomes of using a triple button device for the treatment of displaced distal-third clavicle fractures (Neer, type ii-b). A retrospective review was conducted on a series of patients between November 2...

Forina Michele; Lanteri Silvia; Todeschini Roberto, 2000: Chemometrics for sampling and analysis; theory and environmental applications. Pages 387-404 2000

Trumm, C.G.; Pahl, A.; Helmberger, T.K.; Jakobs, T.F.; Zech, C.J.; Stahl, R.; Paprottka, P.M.; Sandner, T.A.; Reiser, M.F.; Hoffmann, R-Thorsten., 2013: CT fluoroscopy-guided percutaneous vertebroplasty in spinal malignancy: technical results, PMMA leakages, and complications in 202 patients. To retrospectively evaluate the incidence and clinical impact of local polymethylmethacrylate (PMMA) leaks and pulmonary cement embolisms occurring under CT fluoroscopy-guided vertebroplasty of symptomatic malignant vertebral osteolyses. From Dece...

Leliefeld, H.H.; Lutzeyer, W., 1980: Undescended testicle; diagnosis and therapy. Nederlands Tijdschrift Voor Geneeskunde 124(48): 2043-2048

Carrera, G., 1963: Action of UV irradiation on chromogenesis by Pseudomonas aeruginosa. Investigations were carried out on the action of UV irradiation on chromogenesis by P. aeruginosa. It was shown that UV rays inhibit mainly bacterial multiplication and not chromogenesis. The probable mode of action of chloropromazine on chromogen...

Kurtaran, A.; Preitfellner, J.; Schaffarich, P.; Scheuba, C.; Niederle, B.; Virgolini, I.; Havlik, E., 1998: How great is radiation exposure in the area surrounding patients after administration ov 99mTc-sestamibi?. The aim of the present study was to estimate the additional radiation exposure to personnel, other patients and members of the family caused by patients who had been injected with 99mTc-Sestamibi (Cardiolite DuPONT PHARMA) for preoperative localiz...

Nancollas G.H.; Barone J.P., 1977: Influence of fluoride and phosphonate on the mineralization of hydroxylapatite fluor apatite and enamel. Journal of Dental Research 56(SPEC ISSUE A): A154