geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effect of a Chinese herbal medicine mixture on a rat model of hypercholesterolemic erectile dysfunction


, : Effect of a Chinese herbal medicine mixture on a rat model of hypercholesterolemic erectile dysfunction. Journal of Urology 164(5): 1798-1801

We examine the effect of a Chinese herbal medicine mixture on erectile function in a rat model of hypercholesterolemic erectile dysfunction. In this study 32, 3-month-old Sprague-Dawley rats were used. The 8 control animals were fed a normal diet and the remaining 24 were fed 1% cholesterol diet for 4 months. After 2 months herbal medicine was added to the drinking water of the treatment group of 16 rats but not the cholesterol only group of 8. Of the 16 rats 8 received 25 mg./kg. per day (group 1) and 8 received 50 mg./kg. per day (group 2) of Chinese herbal medicine mixture. Serum cholesterol levels were measured at 2 and 4 months. At 4 months erectile function was evaluated with cavernous nerve electrostimulation in all animals. Penile tissues were collected for electron microscopy, and to perform Western blot for endothelial nitric oxide synthase, neuronal nitric oxide synthase, basic fibroblast growth factor (bFGF) and caveolin-1. Serum cholesterol levels were significantly higher in animals fed the 1% cholesterol diet compared to controls at 2 and 4 months. Nevertheless, there was no significant difference among group 1 (145 +/- 30 mg./dl.), group 2 (157 +/- 20) and the cholesterol only group (143 +/- 15). Systemic arterial pressure was not significantly different between the animals that were fed the 1% cholesterol diet and the controls. During electrostimulation of the cavernous nerve peak sustained intracavernous pressure was significantly lower in the cholesterol only group (50 +/- 23 cm. H2O) compared to the control group. Conversely erectile function was not impaired in the herbal medicine treated rats. Electron microscopy showed many caveolae with fingerlike processes in the cavernous smooth muscle and endothelial cell membranes in control and treated rats but not in the cholesterol only group of rats. Western blot did not show a difference among groups in protein expression for endothelial nitric oxide synthase and neuronal nitric oxide synthase in penile tissue but caveolin-1 and bFGF protein expression was significantly higher in groups 1 and 2 than in the cholesterol only and control groups. Rats developed erectile dysfunction after being fed a 1% cholesterol diet for 4 months. Although serum cholesterol levels were similar in the cholesterol only rats and those treated with Chinese herbal medicine mixture, erectile response was significantly better in the treated group. The mechanism of the herbal medicine is unknown. High levels of bFGF and caveolin-1 expression in the treated group may protect the cavernous smooth muscle and endothelial cells from the harmful effect of high serum cholesterol.

US$19.90

PMID: 11025772

DOI: 10.1016/S0022-5347(05)67109-1


Other references

Herlihy A.T.; Mills A.L., 1989: Factors controlling the removal of sulfate and acidity from the waters of an acidified lake. Although Lake anna, an impoundment in Central Virginia, receives acid mine drainage (AMD) from Contrary Creek, the effects of the AMD pollution on the lake are less severe than expected. Previous work at Lake Anna has shown that bacterial sulfate...

Smith, G.I.; Villareal, D.T.; Mittendorfer, B., 2007: Measurement of human mixed muscle protein fractional synthesis rate depends on the choice of amino acid tracer. Measurement of human mixed muscle protein fractional synthesis rate depends on the choice of amino acid tracer. Am J Physiol Endocrinol Metab 293: E666-E671, 2007. First published May 29, 2007; doi:10.1152/ajpendo.00185.2007. - The goal of this s...

Nakagawa, T.L.D.R.; Sakai, H.; Yanai, T.; Kitoh, K.; Mori, T.; Murakami, M.; Masegi, T., 2009: Simultaneous aortic body tumor and pulmonary histiocytic sarcoma in a flat-coated retriever. A case of multiple primary tumors observed in the heart base and in the lung of a 7-year-old intact female, flat-coated retriever was reported. Morphological differences between both tumors and detailed immunohistochemical study revealed that the...

Hance, I.H., 1918: Rhythmical Breathing. Transactions of the American Climatological and Clinical Association. American Climatological and Clinical Association 34: 38-46

Parachnowitsch, A.L.; Kessler, Aé., 2011: Pollinators exert natural selection on flower size and floral display in Penstemon digitalis. • A major gap in our understanding of floral evolution, especially micro-evolutionary processes, is the role of pollinators in generating patterns of natural selection on floral traits. Here we explicitly tested the role of pollinators in select...

Masson, I.F.B.; de Oliveira, B.D.A.; Machado, A.Fernanda.Perez.; Farcic, T.Saikali.; Júnior, I.Esteves.; Baldan, C.Schiavinato., 2014: Manual lymphatic drainage and therapeutic ultrasound in liposuction and lipoabdominoplasty post-operative period. Physiotherapy in the plastic surgery post-operative (PO) is essential to provide means for an adequate and fast recovery as it restores function through the use of physiotherapeutic procedures. The aim of the following study is to verify the effec...

Tripathi, S.N., 1988: Atylosia X Cajanus hybrids - a potential forage legume for drylands. The value of intergeneric hybrids as forage crops is discussed in relation to previous studies. The spreading habit, early maturity, disease resistance and hardiness of Atylosia spp. combined with the high yields, vigour and high seed quality of C...

Clarke, J.F.; Young, P.W.; Yonezawa, K.; Kasuga, M.; Holman, G.D., 1994: Inhibition of the translocation of GLUT1 and GLUT4 in 3T3-L1 cells by the phosphatidylinositol 3-kinase inhibitor, wortmannin. Wortmannin is a potent and reversible inhibitor of insulin-stimulated PtdIns 3-kinase activity in 3T3-L1 cells (IC50 = 2.6 +/- 0.8 nM). Wortmannin inhibits the PtdIns 3-kinase activity which is precipitated with antibodies against insulin receptor...

Celestini, E.; Filocamo, A.; Prota, F.; D.R.ma, S.; Passafaro, S.; Langiano, T.; Fara, G.M.; Guasticchi, G., 2007: Organizational appropriateness evaluation of hospital discharges related to DRGs at high risk of inappropriateness in a pediatric observation ward from 2000 to 2004. The aim of the study is to measure and to describe organizational appropriateness of a Paediatric Temporary Observation Ward in the Emergency Department. We selected hospital discharges related to 43 DRGs at high risk of inappropriateness (DPCM 29...

Palma, J.; Manthe, U., 2015: A Quasiclassical Study of the F((2)P) + CHD3 (ν1 = 0,1) Reactive System on an Accurate Potential Energy Surface. Quasiclassical trajectories (QCT) have been employed to elucidate the effect of exciting the C-H bond in F + CHD3 collisions. The calculations were performed on a new potential energy surface that accurately describes the van der Waals complexes i...