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Folate and carcinogenesis: an integrated scheme


, : Folate and carcinogenesis: an integrated scheme. Journal of Nutrition 130(2): 129-132

Collectively, the evidence from epidemiologic, animal and human studies strongly suggests that folate status modulates the risk of developing cancers in selected tissues, the most notable of which is the colorectum. Folate depletion appears to enhance carcinogenesis whereas folate supplementation above what is presently considered to be the basal requirement appears to convey a protective effect. The means by which this modulation of cancer risk is mediated is not known with certainty, but there are several plausible mechanisms which have been described. Folate plays a major role in the formation of S-adenosylmethionine, the universal methyl donor, as well as in the formation of purine and thymidine synthesis for DNA and RNA. Therefore, most mechanistic studies performed to date have focused on alterations in DNA methylation, disruption of DNA integrity and disruption of DNA repair, all of which have been observed with folate depletion. These aberrations in DNA are believed to enhance carcinogenesis by altering the expression of critical tumor suppressor genes and proto-oncogenes. Recently, the role of a common polymorphism of the methylenetetrahydrofolate reductase gene has been highlighted as well. This review presents those mechanisms which are the most likely candidates to explain folate's effects and it proposes an integrated scheme to explain how these mechanisms might interact. Reprinted by permission of the publisher.

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PMID: 10720158


Other references

Chow,T.E.; Sadler,R., 2010: The consensus of local stakeholders and outside experts in suitability modeling for future camp development. With the emergence of geographic information systems (GIS), suitability analysis has become a modeling practice that facilitates the process of multi-criteria decision making (MCDM) by simulating the suitability of a land unit in supporting a phys...

Gott, V.L.; Lillehei, C.W., 1989: C. Walton Lillehei and his trainees: one man's legacy to cardiothoracic surgery. Between 1951 and 1967, Dr. C. Walton Lillehei trained 134 cardiothoracic surgeons at the University of Minnesota Hospital. Between 1967 and 1979, he trained another 20 surgeons at the New York Hospital-Cornell Medical Center. Twenty-three of these...

Johnson, R.K.; Goran, M.I.; Ferrara, M.S.; Poehlman, E.T., 1996: Athetosis increases resting metabolic rate in adults with cerebral palsy. It was investigated whether resting metabolic rate (RMR) is higher or lower in adults with cerebral palsy. 21 adults with cerebral palsy (9 women, 12 men) were compared with 50 control subjects (25 men, 25 women) within the same age range (18-50 y...

Chrenek, P.; Spaleková, E.; Olexikova, L.; Makarevich, A.; Kubovicova, E., 2017: Quality of Pinzgau bull spermatozoa following different periods of cryostorage. The aim of this work was to examine the influence of cryostorage duration of Pinzgau bull's insemination doses (IDs) on some sperm traits. The IDs were frozen by a slow freezing method and stored in liquid nitrogen for different periods: less...

Bhaud, M.; Duchene, J.-Claude, 1996: Change from planktonic to benthic development: Is life cycle evolution an adaptive answer to the constraints of dispersal?. Current research on recruitment of benthic marine invertebrates is, to a large extent, concerned with the consequences of larval planktonic development in water masses entailing dispersal, a milieu which appears unfavorable for a successful recrui...

Zhang, Y-Ming.; Geng, L.; Huang, D-Wei., 2009: Generate Western blot protein marker from a single construct. An expression construct, consisting of a tandem arrangement of nucleic acids coding for the constant fragments (Fc) receptor of protein G combined with nucleic acids for the Fc receptor of protein A, was constructed. When the construct was express...

Goldberg, D.M.; Blomer, P.R., 1974: An evaluation of the Gilford 3400 automatic enzyme analyzer. Zeitschrift für Klinische Chemie und Klinische Biochemie 12(5): 235-235

Mookerjee, S.; Mallik, U., 1971: Induction of amoebule formation in Amoeba proteus after isoleucine treatment. Nucleus Calcutta, 14: 62-70

Bachir, A.I.; Zareno, J.; Moissoglu, K.; Plow, E.F.; Gratton, E.; Horwitz, A.R., 2015: Integrin-associated complexes form hierarchically with variable stoichiometry in nascent adhesions. A complex network of putative molecular interactions underlies the architecture and function of cell-matrix adhesions. Most of these interactions are implicated from coimmunoprecipitation studies using expressed components, but few have been demon...

Calise, M., 1959: Motility and survival of bull nematospermia from the epididymis and from the ampulla. Archivio di Ostetricia E Ginecologia 64: 539-547