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Genetic variability following selection of Haemonchus contortus with anthelmintics

, : Genetic variability following selection of Haemonchus contortus with anthelmintics. Trends in Parasitology ember; 17(9): 445-453

Genetic diversity in nematodes leads to variation in response to anthelmintics. Haemonchus contortus shows enormous genetic diversity, allowing anthelmintic resistance alleles to be rapidly selected. Anthelmintic resistance is now a widespread problem, especially in H. contortus. Here, I compare the genes involved in anthelmintic resistance in H. contortus with those that confer susceptibility or resistance on the free living nematode Caenorhabditis elegans. I also discuss the latest knowledge of genes associated with resistance to benzimidazoles, levamisole and the macrocyclic lactones and the need for DNA markers for anthelmintic resistance.


PMID: 11530357

DOI: 10.1016/s1471-4922(01)01983-3

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