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Glycyrrhizin enhances interleukin-12 production in peritoneal macrophages

, : Glycyrrhizin enhances interleukin-12 production in peritoneal macrophages. Immunology 103(2): 235-243

Interleukin-12 (IL-12) is a monocyte/macrophage-derived cytokine that plays a prominent role in the development of T helper type 1 cell-mediated immune responses. Glycyrrhizin (GL), an aqueous extract of liquorice root, used as Chinese medicine, is known to have various immunomodulating activities. In this study, GL showed a dose-dependent priming effect on lipopolysaccharide (LPS)-induced IL-12 p40 and IL-12 p70 (heterodimer of p40 and p35) protein production by peritoneal macrophages (PM).


PMID: 11412311

DOI: 10.1046/j.1365-2567.2001.01224.x

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