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Identification of multiple simian immunodeficiency virus (SIV)-specific CTL epitopes in sooty mangabeys with natural and experimentally acquired SIV infection

, : Identification of multiple simian immunodeficiency virus (SIV)-specific CTL epitopes in sooty mangabeys with natural and experimentally acquired SIV infection. Journal of Immunology 164(2): 934-943

To define the specificity of the CTL response in SIV-infected mangabeys (Cercocebus torquatus atys), CTL epitopes were characterized in 2 naturally infected and 3 SIV mac239-infected sooty mangabeys. Compared with that in SIVmac239-infected mangabeys, the yield of SIV-specific CTL clones was significantly lower in naturally infected sooty mangabeys. All CTL clones were phenotypically CD3+ CD8+, and lysis was MHC restricted.


PMID: 10623842

DOI: 10.4049/jimmunol.164.2.934

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