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Inhibiting effects of theanine on caffeine stimulation evaluated by EEG in the rat

, : Inhibiting effects of theanine on caffeine stimulation evaluated by EEG in the rat. Bioscience, Biotechnology, and Biochemistry 64(2): 287-293

In this study, the inhibiting action of theanine on excitation induced by caffeine at the concentration regularly associated with drinking tea was investigated using electroencephalography (EEG) in rats. First, the stimulatory action by caffeine i.v. administration at a level higher than 5 micro mol/kg (0.970 mg/kg) b.w. was shown by means of brain wave analysis, and this level was suggested as the minimum dose of caffeine as a stimulant. Next, the stimulatory effects of caffeine were inhibited by an i.v. administration of theanine at a level higher than 5 micro mol/kg (0.781 mg/kg) b.w., and the results suggested that theanine has an antagonistic effect on caffeine's stimulatory action at an almost equivalent molar concentration. On the other hand, excitatory effects were shown in the rat i.v. administered 1 and 2 micro mol/kg (0.174 and 0.348 mg/kg) b.w. of theanine alone. These results suggested two effects of theanine, depending on its concentration.


PMID: 10737183

DOI: 10.1271/bbb.64.287

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