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Anti-allergic effects of Sanguisorba officinalis on animal models of allergic reactions

, : Anti-allergic effects of Sanguisorba officinalis on animal models of allergic reactions. Immunopharmacology and Immunotoxicology 24(3): 455-468

We investigated the effect of the aqueous extract of S. officinalis root (SOAE) on the immediate-type allergic reactions in vivo and in vitro. SOAE (0.01 to 1 g/kg) inhibited systemic allergic reaction induced by compound 48/80. When SOAE was employed in a systemic allergic reaction test, the plasma histamine levels were reduced in a dose-dependent manner. SOAE (0.001 to 1 g/kg) dose-dependently inhibited passive cutaneous anaphylaxis (PCA) activated by anti-dinitrophenyl (DNP) IgE.


PMID: 12375740

DOI: 10.1081/IPH-120014729

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