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Effect of intravenous infusions of thiamine on the disposition kinetics of thiamine and its pyrophosphate

, : Effect of intravenous infusions of thiamine on the disposition kinetics of thiamine and its pyrophosphate. Journal of Clinical Pharmacy and Therapeutics 28(1): 47-51

Background: Thiamine supplementation is necessary in patients with thiamine deficiency syndromes. Experimental evidence suggests that tissue uptake and the elimination of thiamine are dose-dependent. Aim: The aim of the present study was to investigate the effect of different i.v. infusion rates of thiamine on blood concentrations of thiamine and its active metabolite thiamine pyrophosphate (TPP) and on renal excretion of thiamine.


PMID: 12605618

DOI: 10.1046/j.1365-2710.2003.00462.x

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