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Estimation of the timing of perinatal transmission of HIV

, : Estimation of the timing of perinatal transmission of HIV. Biometrics 57(4): 1048-1058

A temporal estimation of perinatal HIV transmission is presented. The time-dependent sensitivity of DNA and RNA polymerase chain reaction assays are utilized to make nonparametric and semiparametric inferences regarding the distribution of the time of perinatal HIV transmission, together with the cumulative probability of perinatal transmission. The approaches are demonstrated with data from a clinical trial carried out by the AIDS Clinical Trials group.


DOI: 10.1111/j.0006-341x.2001.01048.x

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