+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

IPT1-independent sphingolipid biosynthesis and yeast inhibition by syringomycin E and plant defensin DmAMP1

, : IPT1-independent sphingolipid biosynthesis and yeast inhibition by syringomycin E and plant defensin DmAMP1. FEMS microbiology letters7, 2003 223(2): 199-203

Both bacterial cyclic lipodepsipeptide syringomycin E and plant defensin DmAMP1 were shown previously to require expression of the yeast gene IPT1 for fungicidal action against Saccharomyces cerevisiae. IPT1 encodes a sphingolipid biosynthetic pathway glycotransferase that produces the terminal sphingolipid mannosyldiinositolphosphoceramide. However, when grown in half-strength potato dextrose medium, an ipt1 deletion mutant of S. cerevisiae was observed to be sensitive to syringomycin E and DmAMP1 and to produce small amounts of mannosyldiinositolphosphoceramide. These results show that the terminal sphingolipid but not IPT1 expression is required for fungicidal activity, and they suggest an IPT1-independent route for mannosyldiinositolphosphoceramide biosynthesis.


PMID: 12829286

DOI: 10.1016/s0378-1097(03)00375-6

Other references

Kim, K.Soo., 2016: Headache Attributed to Fibrous Dysplasia of the Ethmoid Bone Mimicking Menstrual Migraine Without Aura. The authors experienced a patient of fibrous dysplasia originating from the ethmoid bone which presented with severe headache with some features suggestive of menstrual migraine without aura. Fibrous dysplasia originating from the ethmoid bone is...

Fengtong, J.; Jiangtao, F.; Yating, W.; Lili, W.; Jianbo, C.; Xiaofei, W., 2017: Effects of S-1 Combined with Radiotherapy in the Treatment of Nasopharyngeal Cancer: A Meta-analysis Based on Randomized Controlled Trials. The aim of this meta-analysis was to evaluate the effects and toxicity of S-1 combined with radiotherapy in the treatment of nasopharyngeal cancer (NPC). Through a search of the databases of PubMed, Embase, the Chinese Biomedicine Database (CBM),...

Monsarrat., 1966: Preliminary observations on Y. guttulata, a pest of sugar-cane in the north-west of Madagascar. Yanga guttulata (Sign.) was first noted as a pest of sugar-cane in north-western Madagascar in 1962 . The nymphs of this Cicadid feed on the roots, weakening the plants and reducing or retarding growth. Up to 200 have been observed per plant. The...

Howie, D.I.D., 1961: The spawning of Arenicola marina (L.) II. Spawning under experimental conditions. Jbiol. Ass. U.K: 127-144

Kappe, C.; Tracy, L.M.; Patrone, C.; Iverfeldt, K.; Sjöholm, Åke., 2013: GLP-1 secretion by microglial cells and decreased CNS expression in obesity. Type 2 diabetes (T2D) is a strong risk factor for developing neurodegenerative pathologies. T2D patients have a deficiency in the intestinal incretin hormone GLP-1, which has been shown to exert neuroprotective and anti-inflammatory properties in...

Pires, A.J.V.; Reis, R.A.; Siqueira, G.R.; Bernardes, T.F.; Bertipaglia, L.M.A.; Resende, K.T. de; Moreno, T.T.B.; Ruggieri, A.C.; Carvalho, G.G.P. de, 2006: Chemical composition of the Brachiaria brizantha hay ammoniated with different moisture. The chemical composition and in vitro dry matter digestibility of Brachiaria brizantha [Urochloa brizantha] hay submitted to (dry matter basis) different urea (3 or 5%) doses and moisture contents (15, 20 or 30%), with or without urease (0 or 3%)...

Ragheb J.A.; Hyman S.L.; Coyle J.T.; Batshaw M.L., 1989: Neurochemical correlates of self injurious behavior. Pediatric Research 25(4 PART 2): 359A

Guo, Y.; Liao, Y-Ping.; Zhang, D.; Xu, L-Sha.; Li, N.; Guan, W-Jun.; Liu, C-Qing., 2014: In vitro study of nucleostemin as a potential therapeutic target in human breast carcinoma SKBR-3 cells. Although nucleolar protein nucleostemin (NS) is essential for cell proliferation and early embryogenesis and expression has been observed in some types of human cancer and stem cells, the molecular mechanisms involved in mediation of cell prolifer...

Cendron, J., 1971: Our experience with rectal bladders. Annales de Chirurgie Infantile 12(6): 444-445

Ali, S.; Ullah, F.; Ullah, H., 2002: Effects of intensity and duration of exercise on total leukocyte count in normal subjects. Leucocytes the mobile units of the protective system of the body, may circulate freely in the blood, adhere to the vascular endothelium in sites where blood flow is relatively slow and then once again re-enter the circulation in a process of conti...