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IQ (2-amino-3-methylimidazo[4,5-f]quinoline)-induced aberrant crypt foci and colorectal tumour development in rats fed two different carbohydrate diets

, : IQ (2-amino-3-methylimidazo[4,5-f]quinoline)-induced aberrant crypt foci and colorectal tumour development in rats fed two different carbohydrate diets. European Journal of Cancer Prevention 10(6): 501-506

Two groups of 26 male F344 rats were each fed continuous doses of 0.03% IQ in a purified diet for 10 or 14 weeks followed by 32 weeks without IQ in the second group. Group I was fed a diet high in corn starch and potato starch while group II was fed a diet high in sucrose and dextrin. 10 animals from each group were sacrificed after 10 weeks and the remaining after 46 weeks. Nine animals were euthenized during weeks 25-44 due to tumours of the skin, mucous membranes, Zymbal gland or liver.


PMID: 11916348

DOI: 10.1097/00008469-200112000-00004

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