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Identification and characterization of Podophyllum emodi by API-LC/MS/MS

, : Identification and characterization of Podophyllum emodi by API-LC/MS/MS. Journal of Mass Spectrometry 35(11): 1246-1251

An API-LC/MS/MS method was developed for the identification of the medicinal herb P. emodi [P. hexandrum] based on the profile of its aryltetrahydronapthalene and related lignan marker compounds. This was done by matching the structural information from the tandem mass spectrometric data with those lignan marker compounds already reported for the herb. The method could be employed in the absence of reference standards for the markers and was particularly useful in view of the scarcity of supply of these chemical standards. It has been used successfully to differentiate P. emodi from two commonly used medicinal herbs of a different genus but having similar appearance, Radix clematidis [Clematis root] and Radix gentiana [Gentiana root], as well as a closely related herb, P. peltatum.


PMID: 11114081

DOI: 10.1002/1096-9888(200011)35:11<1246::AID-JMS55>3.0.CO;2-L

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