+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Identification and characterization of a conserved, stage-specific gene product of Plasmodium falciparum recognized by parasite growth inhibitory antibodies

, : Identification and characterization of a conserved, stage-specific gene product of Plasmodium falciparum recognized by parasite growth inhibitory antibodies. Infection and Immunity 71(4): 2173-2181

We have identified a novel conserved protein of Plasmodium falciparum, designated D13, that is stage-specifically expressed in asexual blood stages of the parasite. The predicted open reading frame (ORF) D13 contains 863 amino acids with a calculated molecular mass of 99.7 kDa and displays a repeat region composed of pentapeptide motives. Northern blot analysis with lysates of synchronized blood stage parasites showed that D13 is highly expressed at the mRNA level during schizogony.


PMID: 12654839

DOI: 10.1128/IAI.71.4.2173-2181.2003

Other references

Wang, G.; Wu, W.W.; Zhang, Z.; Masilamani, S.; Shen, R-Fong., 2008: Decoy methods for assessing false positives and false discovery rates in shotgun proteomics. The potential of getting a significant number of false positives (FPs) in peptide-spectrum matches (PSMs) obtained by proteomic database search has been well-recognized. Among the attempts to assess FPs, the concomitant use of target and decoy dat...

Marzona, E.; Salio, C.; Zugularo, C.; Roberto, C.; Vellano, C.; Giacoma, C., 2002: Biology and conservation of Rana temporaria An educational project Biologia e conservazione di Rana temporaria Un progetto didattico. An educational project was started in the province of Torino in Spring 1996, within the framework of the program "A project for Amphibian conservation". This program has involved 8 classes of primary level, from 4 different schools of Va...

Eichhorn, F.; Dienemann, H.; Muley, T.; Warth, A.; Hoffmann, H., 2015: Predictors of survival after operation among patients with large cell neuroendocrine carcinoma of the lung. Large cell neuroendocrine carcinoma (LCNEC) represents a rare entity in non-small cell lung cancer, with only partially understood biology and poor survival. A diagnosis is difficult to obtain on the basis of small biopsy specimens, but surgical p...

Martin, W., 2010: Evolutionary origins of metabolic compartmentalization in eukaryotes. Many genes in eukaryotes are acquisitions from the free-living antecedents of chloroplasts and mitochondria. But there is no evolutionary 'homing device' that automatically directs the protein product of a transferred gene back to the or...

Carmeliet E., 1992: Diversity of cardiac potassium channels in mechanisms of gating and permeation. Journal of Molecular & Cellular Cardiology 24(SUPPL 1): S24

Hoepner, P.H., 1960: An economic analysis of risk and uncertainty in dairy and hog production. Data for this study were obtained from 149 S.E. and S.W. Minnesota farms. Risk was defined in terms of the standard deviation of the relevant variables. Prices were the most important variables governing fluctuations in income. The variability of...

Rattray, A., 1956: Maize breeding. This review deals briefly with early attempts at maize improvement and describes modern methods of breeding hybrid maize.

Watanabe, T.; Onda, H., 2001: Henoch-Schönlein purpura with antiphospholipid antibodies following an influenza vaccination. Pediatric Nephrology 16(5): 458-9; Discussion 460-2

Vargas Fernández, L.; Meneghello, R.J., 1997: A fortuitous, friendly and fruitful meeting. Memories on the occasion of the National Price in Applied Science and Technology, 1996. Revista Medica de Chile 125(3): 342-345

Tudor, E.C.G.; Hamilton, N.J.I.; Yaghchi, C.A.; Sandhu, G., 2010: The use of an auroscope in the management of epistaxis. Clinical Otolaryngology 35(2): 155-156