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Identification and characterization of a mammalian enzyme catalyzing the asymmetric oxidative cleavage of provitamin A


, : Identification and characterization of a mammalian enzyme catalyzing the asymmetric oxidative cleavage of provitamin A. Journal of Biological Chemistry 276(17): 14110-6

In vertebrates, symmetric versus asymmetric cleavage of beta -carotene in the biosynthesis of vitamin A and its derivatives has been controversially discussed. Recently we have been able to identify a cDNA encoding a metazoan beta , beta -carotene-15,15'-dioxygenase from the fruit fly Drosophila melanogaster. This enzyme catalyses the key step in vitamin A biosynthesis, symmetrically cleaving beta -carotene to give two molecules of retinal.

US$19.90

PMID: 11278918

DOI: 10.1074/jbc.M011510200


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