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Identification and genetic mapping of the mouse Fkbp9 gene encoding a new member of FK506-binding protein family


, : Identification and genetic mapping of the mouse Fkbp9 gene encoding a new member of FK506-binding protein family. Molecules and Cells 12(2): 272-275

We have isolated a gene from a cDNA library generated from the thymus of a mouse with severe combined immune deficiency, termed FKBP9, that encodes a protein related to FK506-binding protein 6 (65 kDa, FKBP65). FKBP9 contains four peptidyl-prolyl cis-trans isomerase (PPIase) signature and two EF-hand domains which is identical to FKBP6/65 in overall structural organization. However, the two proteins share only 66% amino acid identity.

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PMID: 11710534


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