+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Identification and role in virulence of putative iron acquisition genes from Corynebacterium pseudotuberculosis

, : Identification and role in virulence of putative iron acquisition genes from Corynebacterium pseudotuberculosis. FEMS microbiology letters002 208(1): 41-45

Four genes, fagA, B, C and D, encoding products with 32-47% identity to proteins involved in bacterial iron uptake systems, were identified immediately downstream of the Corynebacterium pseudotuberculosis phospholipase D gene. beta-Galactosidase assays on a C. pseudotuberculosis strain carrying a fagA-lacZ fusion indicated that the putative fagABC operon was poorly expressed in iron-rich media. However, similar experiments in iron-limited media resulted in an approximately three-fold increase in beta-galactosidase activity, suggesting that this operon is regulated by iron in vitro. Although no defect in iron utilization could be determined for a C. pseudotuberculosis fagB(C) mutant in vitro, this mutant showed reduced virulence compared to wild-type in a goat model of caseous lymphadenitis. Thus, expression of the fag genes in the host appears to contribute to virulence.


PMID: 11934492

DOI: 10.1111/j.1574-6968.2002.tb11058.x

Other references

Bashaar, M.; Thawani, V.; Hassali, M.Azmi.; Saleem, F., 2017: Erratum to: Disposal practices of unused and expired pharmaceuticals among general public in Kabul. Bmc Public Health 17(1): 231-231

Brotchi, J.; Petrov, V.; Reznik, M., 1974: Arachnoid cysts revealed by cranial traumatism. Acta Neurologica Belgica 74(2): 107-114

Prasad, A.K.S.K.; Nienow, J.A.; Riddle, K.A., 1998: Light and scanning electron microscope observations of an interesting synedroid diatom from Florida Bay, USA. Journal of Phycology 34(3 SUPPL ): 49, June

Schuz, E., 1954: Zur Verbritung des Weissstorches im Oberrheingebiet. Jahresheft des Vereins fuer Vaterlaendische Naturkunde in Wuerttemberg, 1091: 141-144

Catara, A.; Polizzi, G., 1999: Dry root rot of citrus: symptoms, causes and susceptibility of rootstocks. The symptoms of damage, geographic distribution, economic importance, epidemiology and control of dry root rot of citrus, associated with Fusarium spp. and particularly F. solani, are described. The occurrence of dry root rot of citrus is increasi...

Latalski, M.; Obuchowska, D.; Spruch, T., 1983: Study of the ultrastructure of epithelial cells of the seminal vesicles of rats after inhibition of the gonadotropic function of the anterior pituitary gland. Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina 38: 155-162

Mckeehan, W.L.; Wang, F.; Kan, M., 1998: The heparan sulfate-fibroblast growth factor receptor signal transduction complex Structure-function relationships. Journal of Endocrinology 156(SUPPL ): S26, March

de Ruiz Holgado, A.P.; Raya, J.M.; D.N.der, O.R.; Rossini deCastagnaro, N.; D.V.lladares, R.R.; Martínez, M., 1968: First epidemilogical survey of influenza in Tucumán, Argentina. Boletin de la Oficina Sanitaria Panamericana. Pan American Sanitary Bureau 64(4): 328-331

Kessler, H.G., 1995: Overview and limits of alternative methods for reducing or destroying microorganisms. Possibilities and limits of alternative methods for reducing or eliminating microorganisms in milk are discussed, using 5 processes as examples. These are microfiltration, radiation treatment, conductive heating, microwaving and high pressure trea...

Jones, H.Gwynne, 1961: Learning and abnormal behaviour. H J Eysenck, Editor Handbook of Abnormal Psychology 488-528