geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Differential effects of isoflavones and lignans on invasiveness of MDA-MB-231 breast cancer cells in vitro


, : Differential effects of isoflavones and lignans on invasiveness of MDA-MB-231 breast cancer cells in vitro. Cancer Letters 208(1): 35-41

Metastasis is a major cause of morbidity and mortality in breast cancer with tumour cell invasion playing a crucial role in the metastatic process. The effects of a panel of phytoestrogens, including isoflavones and lignans on the invasion of a breast cancer cell-line (MDA-MB-231) through Matrigel were assessed. Genistein, glycitein, daidzein, equol, O-Desmethylangolensin (O-Dma) and coumestrol exerted a potent inhibitory effect on cell invasion (e.g. inhibition of 41.7+or-15% (P=0.007); coumestrol (10 micro M)). In contrast the lignans exerted minimal effects on invasion. Inhibition of invasion induced by the phytoestrogens occurred without affecting cell viability, highlighting the possible chemoprotective effects of these compounds.

US$19.90

PMID: 15105043

DOI: 10.1016/j.canlet.2003.11.012


Other references

Lenders, J.W.M.; Willemsen, J.J.; Eisenhofer, G.; Ross, H.Alec.; Pacak, K.; Timmers, H.J.L.M.; Sweep, C.G.J.Fred., 2007: Is supine rest necessary before blood sampling for plasma metanephrines?. Background: The impact of blood sampling in sitting vs supine positions on measurements of plasma metanephrines for diagnosis of pheochromocytoma is unknown.Methods: We compared plasma concentrations of free metanephrines in samples from patients...

Nadim, F.; Walid, H.; Adib, J., 2002: The differential diagnosis of crystals in the retina. Crystalline deposits in the retina may be associated with a wide variety of systemic disorders such as oxalosis, cystinosis, hyperornithinaemia and Sjögren-Larsson syndrome. Refractile crystalline deposits may also be a manifestation of drug toxi...

Ghaly A.E.; A.T.weel A., 1990: Thermal degradation of cereal straws in air. The thermogravimetric behavior of four central straws (wheat, barley, oats, and rye) at three heating rates (10, 20, and 50.degree. C/min) in air was examined. The thermal degradation rate, the initial degradation temperature, the active and passi...

Falter, U., 1985: Verhaltensforschung R. Apfelbach and J. Döhl. 3 rd Edition, UTB 210, Gustav Fischer Verlag, Stuttgart and New York, 1980. 193 pp., DM 12.80 ISBN 3-437-20236-7. Behavioural Processes 10(1-2): 201-201

Jourdan, M.H., 1972: The incorporation of fructose and glucose, given intravenously, into the serum lipids of baboons. Fasting adult male and female baboons [Papio papio] were given an injection of either fructose or glucose, 0.5 g/kg bodyweight as a 20% solution containing fructose-U-14C or glucose-U-14C such that each animal received about 2 mu Ci/kg bodyweight....

Dorn, J.; Schisterman, E.; Winkelstein, W.; Trevisan, M., 1996: Principal components analysis of work and leisure-time physical activity and the long-term survival of a general population sample. American Journal of Epidemiology 143(11 SUPPL ): S73

Lal, S.; Ali, S.; Dewey, R.; Millan, E.; Lowenstein, P.; Castro, M.; Watson, A.J.M., 1998: Adenovirus vectors for gene transfer into colorectal cancer cells for gene therapy. Gut 42(SUPPL 1): A1, March

Froment A., 1971: The upland moss hags of roannay at francorchamps. Natura Mosana 24(4): 85-92

Leeman, J.E.; Kim, J.S.; Yu, F.T.H.; Chen, X.; Kim, K.; Wang, J.; Chen, X.; Villanueva, F.S.; Pacella, J.J., 2013: Effect of acoustic conditions on microbubble-mediated microvascular sonothrombolysis. Ultrasound (US) mediated microbubble (MB) destruction facilitates thrombolysis of the epicardial coronary artery in acute myocardial infarction (AMI) but its effect on microvascular thromboemboli remains largely unexplored. We sought to define the...

Auger, P.; Désilets, J.; Bernard, D.; Roussin, M.L.; Poliquin, J.; Robert, J.; Steben, M., 1990: Screening pregnant women for Chlamydia--Quebec. Canada Diseases Weekly Report 16(10): 45-46