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Group B vitamins protect murine cerebellar granule cells from glutamate/NMDA toxicity

, : Group B vitamins protect murine cerebellar granule cells from glutamate/NMDA toxicity. Neuroreport 15(14): 2241-2244

The role of B group vitamins in preventing neuronal death against excitotoxicity was investigated. Neuronal death of cultured mouse cerebellar granule neurons (CGNs) caused by glutamate (50 ) or NMDA (200 (mu)M) was delayed in CGNs that had been treated with riboflavin, folic acid or cyanocobalamin for 18 h. Neuroprotection by the 3 vitamins was observed in a dose- and time-dependent manner.


PMID: 15371742

DOI: 10.1097/00001756-200410050-00020

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