+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Imported malaria is a major cause of thrombocytopenia in children presenting to the emergency department in east London

, : Imported malaria is a major cause of thrombocytopenia in children presenting to the emergency department in east London. British Journal of Haematology 129(5): 707-709

A retrospective study was conducted to determine the causes of thrombocytopenia in children presenting to the Emergency Department of Newham Hospital in East London, UK between January and December 2002. Sixty-five children (38 boys; aged 3-9 years) were included in the study. Malaria accounted for 46% (30 of 65) of all cases of thrombocytopenia and 61% (30 of 49) of infectious causes of thrombocytopenia. Plasmodium falciparum was the aetiological agent in 27 cases, Plasmodium vivax in two cases, and Plasmodium ovale in one case. Malaria was diagnosed in 29% (two of five), 61% (11 of 18), and 43% (17 of 40) children with platelet counts of <50x109/litre, 50-99x109/litre and 100-149x109/litre, respectively. The children with thrombocytopenia and malaria were non-white, with history of foreign travel in the past six months, and fever compared with thrombocytopenic children without malaria. Malaria was diagnosed in 30 of 33 children with thrombocytopenia and history of travel to a malaria-endemic country in the past six months, giving a positive predictive value of 91%. Three children with malaria and thrombocytopenia had negative results at initial screening. The findings indicate that children with thrombocytopenia and history of foreign travel have 91% risk of having malaria regardless of taking antimalarial prophylaxis. This is the first study to show that malaria is a significant cause of thrombocytopenia in children presenting to the emergency department. It is recommended that malaria should be considered in the differential diagnosis for any child with thrombocytopenia, especially if there is a history of recent foreign travel and/or fever, even if the initial malaria screening result is negative. In addition, blood samples with thrombocytopenia in the emergency department should undergo routine screening for malaria in hospitals catering to large multi-ethnic populations.


PMID: 15916695

DOI: 10.1111/j.1365-2141.2005.05522.x

Other references

Derums, V.Ia., 1968: On the development of surgery of bone injuries on the Baltic coast (based on data of archeological findings). Ortopediia Travmatologiia i Protezirovanie 29(3): 86-89

Sulewska, M.; Duraj, E.; Sobaniec, S.; Graczyk, A.; Milewski, R.; Wróblewska, M.; Pietruski, J.; Pietruska, Młgorzata., 2017: A clinical evaluation of the efficacy of photodynamic therapy in the treatment of erosive oral lichen planus: A case series. Erosive oral lichen planus (EOLP) poses a substantial risk of malignant transformation into squamous cell cancer. The absence of established treatment gives way to alternative therapeutic strategies, including photodynamic therapy. The aim of the...

Hitomi, Y.; McDonnell, W.M.; Killeen, A.A.; Askari, F.K., 1995: Sequence analysis of the hepatitis C virus (HCV) core gene suggests the core protein as an appropriate target for HCV vaccine strategies. Hepatitis C virus (HCV) is a major healthproblem with a prevalence of 1% in the United States population, and a significant percentage of infected patients progress to chronic liver disease and cirrhosis. Interferon therapy has demonstrated that t...

Cunningham, E., 2007: My encounter with hospice. Beginnings 27(4): 10-11

Mijac, M.; Domnić-Stosić, T., 1980: Relationship of the mylohyoid artery and mylohyoid nerve in the mylohyoid groove. Stomatoloski Glasnik Srbije 27(5): 405-409

Marwick J.; Singleton F.A., 1947: Correlation of Tertiary rocks of Australia and New Zealand committee. Summarizes recent research.

Zodac Peter, 1937: Minerals of the Strickland quarry. Rocks and Minerals 12(5): 131-144

Tournoy, J.; Lee, D.M.; Pendleton, N.; O'Neill, T.W.; O'Connor, D.B.; Bartfai, G.; Casanueva, F.F.; Finn, J.D.; Forti, G.; Giwercman, A.; Han, T.S.; Huhtaniemi, I.T.; Kula, K.; Lean, M.E.J.; Moseley, C.M.; Punab, M.; Silman, A.J.; Vanderschueren, D.; Wu, F.C.W.; Boonen, S.; Forti, G.; Petrone, L.; Corona, G.; Vanderschueren, D.; Boonen, S.; Borghs, H.; Kula, K.; Slowikowska-Hilczer, J.; Walczak-Jedrzejowska, R.; Huhtaniemi, I.; Giwercman, A.; Wu, F.; Silman, A.; O'Neill, T.; Finn,, 2011: Association of cognitive performance with the metabolic syndrome and with glycaemia in middle-aged and older European men: the European Male Ageing Study. Metabolic syndrome has been reported to have adverse effects on cognition although the results are conflicting. We investigated the association between metabolic syndrome and cognitive function in a population sample of middle-aged and older Europ...

Rodari, T., 1960: Determination of insulin in the blood by the immunological method in normal subjects. Bollettino Della Societa Italiana di Biologia Sperimentale 36: 560-561

Yang, Y.; James, S.St.; Wu, Y.; Du, H.; Qi, J.; Farrell, R.; Dokhale, P.A.; Shah, K.S.; Vaigneur, K.; Cherry, S.R., 2011: Tapered LSO arrays for small animal PET. By using detectors with good depth encoding accuracy (∼2 mm), an animal PET scanner can be built with a small ring diameter and thick crystals to simultaneously obtain high spatial resolution and high sensitivity. However, there will be large we...