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Obesity in middle age and future risk of dementia: a 27 year longitudinal population based study


, : Obesity in middle age and future risk of dementia: a 27 year longitudinal population based study. Bmj 330(7504): 1360-1360

Objective: To evaluate any association between obesity in middle age, measured by body mass index and skin fold thickness, and risk of dementia later in life. Design: Analysis of prospective data from a multiethnic population based cohort. Setting: Kaiser Permanente Northern California Medical Group, a health care delivery organization in San Francisco and Oakland, California, USA. Participants: 10 276 men and women who underwent detailed health evaluations from 1964 to 1973 when they were aged 40-45 years and who were still members of the health plan in 1994. Main outcome measures: Diagnosis of dementia from January 1994 to April 2003. Time to diagnosis was analysed with Cox proportional hazard models adjusted for age, sex, race, education, smoking, alcohol use, marital status, diabetes, hypertension, hyperlipidaemia, stroke, and ischaemic heart disease. Results: Dementia was diagnosed in 713 (6.9%) participants. Obese people (body mass index>=30) had a 74% increased risk of dementia (hazard ratio 1.74, 95% confidence interval 1.34 to 2.26), while overweight people (body mass index 25.0-29.9) had a 35% greater risk of dementia (1.35, 1.14 to 1.60) compared with those of normal weight (body mass index 18.6-24.9). Compared with those in the lowest fifth, men and women in the highest fifth of the distribution of subscapular or tricep skinfold thickness had a 72% and 59% greater risk of dementia, respectively (1.72, 1.36 to 2.18, and 1.59, 1.24 to 2.04). Conclusions: Obesity in middle age increases the risk of future dementia independently of comorbid conditions. This is an abridged version of an article that is posted on bmj.com (http://bmj.com/cgi/doi/10.1136/bmj.38446.466238.EO).

US$19.90

PMID: 15863436

DOI: 10.1136/bmj.38446.466238.E0


Other references

Matic, M.; Matic, A.; Djuran, V.; Gajinov, Z.; Prcic, S.; Golusin, Z., 2016: Frequency of Peripheral Arterial Disease in Patients With Chronic Venous Insufficiency. It is estimated that about 15% (10% - 30% in most of the studies) of the total adult population has some aspects of the Chronic Venous Insufficiency (CVI). Frequency of the Peripheral Arterial Disease (PAD) in the adult population is 3% - 4%. Stud...

Mainous, E.G.; Crowell, N.T., 1973: Nasal septum perforation following total maxillary osteotomy: report of case. Journal of Oral Surgery 31(11): 869-872

Yang, H-Fu.; Xu, S-Hai., 2010: catena-Poly[[[tetra-aqua-erbium(III)]-μ-oxalato-κO,O:O,O] [bromidobis(pyrazine-2-carboxyl-ato-κN,O)cuprate(II)] tetra-hydrate. In the title heterometallic complex, {[Er(C(2)O(4))(H(2)O)(4)][CuBr(C(5)H(3)N(2)O(2))(2)]·4H(2)O}(n), the Er(III) atom is eight-coordin-ated by four O atoms from two centrosymmetric oxalate ligands and four water mol-ecules, displaying a bicapped...

Griffith, A.J.; Wangemann, P., 2012: Hearing loss associated with enlargement of the vestibular aqueduct: mechanistic insights from clinical phenotypes, genotypes, and mouse models. Enlargement of the vestibular aqueduct (EVA) is one of the most common inner ear malformations associated with sensorineural hearing loss in children. The delayed onset and progressive nature of this phenotype offer a window of opportunity to prev...

Tuisheva, R.M., 1955: Factors which lower the resistance of the organism to experimental rabies. White mice were experimentally injected intramuscularly with the fixed virus of rabies; 14% died. Some of the fixed virus injected mice were subjected to fatigue, cooling and to the effect of alcohol; 34-37% of these mice became specifically ill.

Evju, M.; Austrheim, G.; Halvorsen, R.; Mysterud, A., 2009: Grazing responses in herbs in relation to herbivore selectivity and plant traits in an alpine ecosystem. Herbivores shape plant communities through selective foraging. However, both herbivore selectivity and the plant's ability to tolerate or resist herbivory may depend on the density of herbivores. In an alpine ecosystem with a long history of...

Shanafelt, T.; Hanson, C.A., 2009: Monoclonal B-cell lymphocytosis: definitions and natural history. The diagnostic term monoclonal B-cell lymphocytosis (MBL) is used to characterise individuals with a circulating population of clonal B-cells, a total B-cell count of <5 x 10(9)/L, and no other features of a B-cell lymphoproliferative disorder....

Li, X.M.; Li, L.Z.; Chen, S.L.; Qiu, X.H.; Yu, Y.H.; Pan, D.X.; Zou, L.L.; Yang, Z.L.; Han, Y.S., 1984: Inhibitory effects of sophocarpine on animal tumors. Sophocarpine, an alkaloid isolated from Sophora alopecuroides L., is a new type of drug for choriocarcinoma. In mice, rats and 615 inbred mice, the transplanted tumors of S180, U14, Lio1, W256, and L615 were inhibited moderately by sophocarpine. T...

Li, M.; Chen, X.; Guo, Y.; Zhang, B.; Tang, F.; Wu, X., 2016: Enhanced sensitivity and resolution for the analysis of paralytic shellfish poisoning toxins in water using capillary electrophoresis with amperometric detection and field-amplified sample injection. NlmCategory="UNASSIGNED">The profiling of the most lethal paralytic shellfish poisoning toxins (PSTs) in freshwater has increased the need to establish an alternative analytical method with high sensitivity and resolution. In this pap...

Caruba, A., 1979: Today and tomorrow in brewery pest control. Pest control 47(10): 16-18