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Pathophysiology and treatment of obesity hypertension

, : Pathophysiology and treatment of obesity hypertension. Current Pharmaceutical Design 10(29): 3621-3637

Excess weight gain accounts for as much as 65-75% of the risk for essential hypertension and also greatly increases the risk for end stage renal disease (ESRD). Obesity raises blood pressure by increasing renal tubular reabsorption, impairing pressure natriuresis, and causing volume expansion due to activation of the sympathetic nervous system (SNS) and renin-angiotensin aldosterone system (RAAS), and by physical compression of the kidneys, especially when visceral obesity is present.


PMID: 15579059

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