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Selenium and its relationship to cancer: an update


, : Selenium and its relationship to cancer: an update. British Journal of Nutrition 91(1): 11-28

Selenomethionine (Semet) is the major seleno-compound in cereal grains and enriched yeast whereas Se-methylselenocysteine (SeMCYS) is the major seleno-compound in Se-accumulator plants and some plants of economic importance such as garlic and broccoli exposed to excess Se. Animals can metabolize both Semet and SeMCYS. Epidemiological studies have indicated an inverse relationship between Se intake and the incidence of certain cancers. Blood or plasma levels of Se are usually lower in patients with cancer than those without this disorder, but inconsistent results have been found with toenail-Se values and the incidence of cancer. There have been eight trials with human subjects conducted on the influence of Se on cancer incidence or biomarkers, and except for one, all have shown a positive benefit of Se on cancer reduction or biomarkers of this disorder. This is consistent with about 100 small-animal studies where Se has been shown to reduce the incidence of tumours in most of these trials. Se-enriched yeast is the major form of Se used in trials with human subjects. In the mammary-tumour model, SeMCYS has been shown to be the most effective seleno-compound identified so far in reduction of tumours. Several mechanisms have been proposed on the mechanism whereby Se reduces tumours. Even though SeMCYS was shown to be the most effective seleno-compound in the reduction of mammary tumours, it may not be the most effective seleno-compound for reduction of colon tumours. Reprinted by permission of the publisher.

US$19.90

PMID: 14748935

DOI: 10.1079/BJN20031015


Other references

Bakrania, S.D.; Wooldridge, M.S., 2012: The effects of the location of Au additives on combustion-generated SnO(2) nanopowders for CO gas sensing. The current work presents the results of an experimental study of the effects of the location of gold additives on the performance of combustion-generated tin dioxide (SnO(2)) nanopowders in solid state gas sensors. The time response and sensor re...

Albert, J.D.; Matthews, D.E.; Legaspi, A.; Tracey, K.J.; Jeevanandam, M.; Brennan, M.F.; Lowry, S.F., 1989: Exercise-mediated peripheral tissue and whole-body amino acid metabolism during intravenous feeding in normal man. 1. The effect of a daily submaximal exercise regimen on whole-body and peripheral tissue amino acid metabolism during weight-stable intravenous feeding (IVF) was evaluated in 11 normal volunteers. Five of the subjects performed 1 h of daily bicycl...

Anonymous, 1927: University And Educational Notes. Science 65(1679): 229-229

Ludwig, A., 2002: When the nurse becomes a family member. Pflege Aktuell 56(10): 538-541

Allred, D.M.; Beck, D.E.; Jorgensen, C.D., 1963: Biotic communities of the Nevada Test Site. Science Bulletin Brigham Young University Biol Series, 2: 1-52

Levy J.; Karny G.; Wicher K., 1971: Comparison of 3 methods for detecting significant bacteriuria in urines. Bacteriological Proceedings 71: 83

Campos-Outcalt, D., 2007: Practice alert: CDC no longer recommends quinolones for treatment of gonorrhea. Journal of Family Practice 56(7): 554-558

Spiegel, L.R.; Schneider, R.; Lang, B.A.; Birdi, N.; Silverman, E.D.; Laxer, R.M.; Stephens, D.; Feldman, B.M., 2000: Early predictors of poor functional outcome in systemic-onset juvenile rheumatoid arthritis: a multicenter cohort study. Objective. To examine the ability of a previously described set of criteria to predict poor functional outcome in a large, multicenter cohort of children with systemic-onset juvenile rheumatoid arthritis (JRA). Methods. All children who were diagn...

Stacey A.R.; Newell D.G., 1990: Local and systemic immune responses during helicobacter pylori infections. Journal of Medical Microbiology 33(2): V

Murohashl, T.; Yoshida, K.; Kato, M., 1965: A simple method to differentiate Mycobacterium avium from non-photochromogens by the effect of ultraviolet irradiation on acid-fastness. A simple method for differentiating M. avium from nonphotochromogens was devised. When smear preparations of bacilli were irradiated by UV rays and tested for the loss of acidfastness, cells of M. avium showed much slower loss than the nonphotochr...