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The effect of Smallanthus sonchifolius leaf extracts on rat hepatic metabolism

, : The effect of Smallanthus sonchifolius leaf extracts on rat hepatic metabolism. Cell Biology and Toxicology 20(2): 109-120

Smallanthus sonchifolius (yacon), originating from South America, has become popular in Japan and in New Zealand for its tubers which contain beta-1,2-oligofructans as the main saccharides. The plant is also successfully cultivated in Central Europe in the Czech Republic in particular. Its aerial part is used in Japan and in Brazil as a component in medicinal teas; while aqueous leaf extracts have been studied for their hypoglycemic activity in normal and diabetic rats. We have already demonstrated the high content of phenolic compounds in yacon leaf extracts and their in vitro antioxidant activity. In this paper, we present the effects of two organic fractions and two aqueous extracts from the leaves of S. sonchifolius on rat hepatocyte viability, on oxidative damage induced by tert-butyl hydroperoxide (t-BH) and allyl alcohol (AA), and on glucose metabolism and their insulin-like effect on the expression of cytochrome P450 (CYP) mRNA. All the extracts tested exhibited strong protective effect against oxidative damage to rat hepatocyte primary cultures in concentrations ranging from 1 to 1000 microg/ml, reduced hepatic glucose production via gluconeogenesis and glycogenolysis at 1000 microg/ml. Moreover, the effects of the organic fractions (200 and 250 microg/ml) and to a lesser extent, the tea infusion (500 microg/ml) on rat CYP2B and CYP2E mRNA expression, were comparable to those observed with insulin. The combination of radical scavenging, cytoprotective and anti-hyperglycemic activity predetermine S. sonchifolius leaves for use in prevention and treatment of chronic diseases involving oxidative stress, particularly diabetes.


PMID: 15242186

DOI: 10.1023/b:cbto.0000027931.88957.80

Other references

Bottcher, W., 1974: Introduction to production of new generation of automatically controlled sprinkling pump stations. Feldwirtschaft 15 (5) 221-223

Katsanis, S.H.; Dungan, J.R.; Gilliss, C.L.; Ginsburg, G.A., 2014: Educating future providers of personalized medicine. North Carolina Medical Journal 74(6): 491-492

Belmaker, R.; Pollin, W.; Wyatt, R.J.; Cohen, S., 1974: A follow-up of monozygotic twins discordant for schizophrenia. Archives of General Psychiatry 30(2): 219-222

Hadziomerovic, Z.; Dzuvic, A., 1975: Minute actinobacillosis lesions in the mandibular lymph nodes of swine. Histological examination of mandibular lymph nodes from 132 pigs slaughtered for suspected tuberculosis showed lesions of actinobacillosis in 12 cases. Tiny colonies, believed to be of Actinobacillus lignieresi, were detected. Some of the colonies...

Teodorczyk, M.; Schmidt, M.H.H., 2015: Notching on Cancer's Door: Notch Signaling in Brain Tumors. Notch receptors play an essential role in the regulation of central cellular processes during embryonic and postnatal development. The mammalian genome encodes for four Notch paralogs (Notch 1-4), which are activated by three Delta-like (Dll1/3/4)...

Dundee, J.W., 1972: Effect of fructose on blood-alcohol levels. Lancet 2(7786): 1086-1086

Li, X-Fei.; Liao, X-Yi.; Liu, Y-Feng.; Guo, L-Qiong.; Ye, Z-Wei.; Lin, J-Fang., 2014: Complete Genome Sequence of Probiotic Lactobacillus plantarum Strain FMNP01, Isolated from Mango Fruit. Lactobacillus plantarum strain FMNP01 is a new strain with probiotic properties that was isolated from fresh mango from Guangzhou, China. Here, we report the complete genome of this organism.

Mouz, N.; Gordon, E.; D.G.ilmi, A.M.; Vernet, T.; Dideberg, O., 1998: Identification of structural determinants for Streptococcus pneumoniae PBP2x resistance to beta-lactam antibiotics. Abstracts of the General Meeting of the American Society for Microbiology 98: 534

Blagonravova, L.; Shcherbanovskii, L., 1975: Effect of 1,4-naphthoquinones and saponins on the activity of polyphenoloxidase (in vitro). Fiziologo biokhimicheskie osnovy vzaimodeistviia rastenii v Fitotsenozakh: 37-39

Anonymous, 1970: Tolbutamide (Orinase) and diabetes. Medical Letter on Drugs and Therapeutics 12(24): 97-98