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Vaccine adjuvant technology: from theoretical mechanisms to practical approaches


, : Vaccine adjuvant technology: from theoretical mechanisms to practical approaches. Developments in Biologicals 121: 127-134

Poorly immunogenic antigens depend on vaccine adjuvants to evoke an immune response. In addition, adjuvants largely determine the magnitude, quality, time of onset and the duration of immune responses to co-administered antigens. As late as 1989, Janeway aptly called adjuvants: "the immunologist's dirty little secret". This statement reflected the ignorance on the mechanisms of action of most known adjuvants.

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PMID: 15962475


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