geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

A multicenter randomized trial evaluating posaconazole versus fluconazole for the treatment of oropharyngeal candidiasis in subjects with HIV/AIDS


, : A multicenter randomized trial evaluating posaconazole versus fluconazole for the treatment of oropharyngeal candidiasis in subjects with HIV/AIDS. Clinical Infectious Diseases 42(8): 1179-1186

Background. Oropharyngeal candidiasis is the most common opportunistic infection among persons infected with human immunodeficiency virus (HIV). Use of some agents is hampered by lack of efficacy, emergence of resistance, adverse events, and need for intravenous administration. Posaconazole is an extended-spectrum triazole with potent in vitro activity against Candida species, including Candida albicans, Candida glabrata, and Candida krusei (including fluconazole-resistant strains). Methods. This multicenter, randomized, evaluator-blinded study of subjects with HIV infection and oropharyngeal candidiasis compared efficacy of posaconazole with that of fluconazole. Subjects received either 200 mg of posaconazole or fluconazole oral suspension on day 1, followed by 100 mg/day for 13 days. The primary study end point - clinical success (cure or improvement) on day 14 - was evaluated for 329 subjects. Durability of clinical success was evaluated on day 42. Results. Three hundred fifty subjects received posaconazole (n=178) or fluconazole (n=172). Clinical success occurred in 155 (91.7%) of 169 posaconazole recipients and in 148 (92.5%) of 160 fluconazole recipients (95% confidence interval, -6.61% to 5.04%), indicating that posaconazole was not inferior to fluconazole. On day 14, mycological success was 68% in both arms, but by day 42, significantly more posaconazole recipients than fluconazole recipients continued to have mycological success (40.6% vs. 26.4%; P=.038). Fewer posaconazole recipients than fluconazole recipients experienced clinical relapse (31.5% vs. 38.2%). Adverse events were similar between treatment arms. Conclusions. Results demonstrate that posaconazole was as effective as fluconazole in producing a successful clinical outcome. However, posaconazole was more effective in sustaining clinical success after treatment was stopped.

US$19.90

PMID: 16575739

DOI: 10.1086/501457


Other references

Husson, A.M., 1959: On the systematic position of the western hamster, Cricetus cricetus canescens Nehring (Mammalia : Bodentia). Bijdragen tot de Dierkunde, 29: 187-201

Beutler, D.; Avoledo, P.; Reubi, J-Claude.; Mäcke, H.R.; Müller-Brand, J.; Merlo, A.; Kühne, T., 2005: Three-year recurrence-free survival in a patient with recurrent medulloblastoma after resection, high-dose chemotherapy, and intrathecal Yttrium-90-labeled DOTA0-D-Phe1-Tyr3-octreotide radiopeptide brachytherapy. BACKGROUND. Most medulloblastomas express high levels of somatostatin type 2 receptors (sst2). DOTA0-D-Phe1-Tyr3-octreotide (DOTATOC) specifically binds sst2 in the low nanomolar range. The cytotoxic effect is mediated by the chelated, P-emitting,...

Fahnestock, G.R., 1953: Relative humidity and fire behaviour in logging slash. Results of experiments in slash burning on 36 plots at a time when relative humidity was increasing rapidly, showed a rapid reduction in rate of spread as humidity increased on plots with light and medium slash (7.5 and 20 tons dry weight/acre res...

Muirhead, P.E.; Butcher, G.; Rankin, J.; Munley, A., 2006: The effect of a programme of organised and supervised peer support on the initiation and duration of breastfeeding: a randomised trial. Peer support may improve breastfeeding rates but the evidence is inconclusive. Previous studies and reviews recommend trials in different healthcare settings. To test if a specified programme of peer support affects the initiation and/or the durat...

Moiseyev Alexis N., 1974: Serpentinite-water interaction at 200-260 degrees C and 1 Kbar; a preliminary report. Eos, Transactions, American Geophysical Union 55(4): 478

Olin, G.A., 2003: Why this arrogance, Josef Milerad?. Lakartidningen 100(4): 254-255

Aures, D.; Håkanson, R.; Owman, C., 1970: Formation and storage of amines in endocrine cells of gastric mucosa. Journal of Neuro-Visceral Relations 31(4): 337-349

Lohmann, F.W., 1999: Treatment of isolated systolic hypertension: A comparative study of felodipine, ramipril and isosorbide mononitrate in 1041 patients. Background: A loss of elasticity of the aortic arch and major arteries near the heart, with acceleration of the pulse wave and amplification of this effect in the periphery, leads to isolated systolic arterial hypertension (ISH). According to expe...

Moseley Frank; Walker D., 1952: Some aspects of the Quaternary period in north Lancashire. Discusses the extent and effects of Pleistocene glaciation in northern Lancashire, England, with particular reference to stages in the retreat of the principal ice sheet (the Lonsdale glacier) and drainage modifications, and outlines the postglaci...

Smyth, M.J.; Strobl, S.L.; Young, H.A.; Ortaldo, J.R.; Ochoa, A.C., 1991: Regulation of lymphokine-activated killer activity and pore-forming protein gene expression in human peripheral blood CD8+ T lymphocytes. Inhibition by transforming growth factor-beta. The effect of transforming growth factor-beta 1 (TGF-beta) on activation-induced CD8+ T cell cytotoxicity and gene expression was investigated. TGF-beta was demonstrated to inhibit pore-forming protein (PFP) mRNA expression and total benzoyloxycar...