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A survival-adjusted quantal-response test for analysis of tumor incidence rates in animal carcinogenicity studies

, : A survival-adjusted quantal-response test for analysis of tumor incidence rates in animal carcinogenicity studies. Environmental Health Perspectives 114(4): 537-541

In rodent cancer bioassays, groups of animals are exposed to different doses of a chemical of interest and followed for tumour occurrence. The resulting tumor rates are commonly analysed using a survival-adjusted Cochran-Armitage (CA) trend test. The CA trend test has reasonable power when the tumour-response curve is linear in dose, but it may be underpowered for a nonlinear response.


PMID: 16581542

DOI: 10.1289/ehp.8590

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