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Introduction of an additional pathway for lactate oxidation in the treatment of lactic acidosis and mitochondrial dysfunction in Caenorhabditis elegans


, : Introduction of an additional pathway for lactate oxidation in the treatment of lactic acidosis and mitochondrial dysfunction in Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America 102(51): 18367-18372

Mitochondrial dysfunction, with an estimated incidence of 1 in 5,000 births, is associated with a wide variety of multisystem degenerative diseases. Among the most prevalent forms of dysfunction are defects in the NADH:ubiquinone oxidoreductase (complex I). Caenorhabditis elegans strains with complex I mutations exhibit characteristic features of human mitochondrial disease including decreased rates of respiration and lactic acidosis. We hypothesized that introducing an additional pathway for the direct oxidation of lactate would be beneficial for energy metabolism. The yeast CYB2 gene encodes an L-lactate:cytochrome c oxidoreductase that oxidizes lactate, donates electrons directly into the mitochondrial respiratory chain, and supports lactate-dependent respiration. Cyb2p expression markedly increases lifespan, fertility, respiration rates, and ATP content in complex I-deficient animals. Our results indicate that metabolic imbalance leading to lactic acidosis and energy depletion are central mechanisms of pathogenesis in mitochondrial dysfunction and that introduction of an additional pathway for lactate oxidation should be considered as a treatment.

US$19.90

PMID: 16344465

DOI: 10.1073/pnas.0506939102


Other references

Jin, H.; Zastawny, R.; Moldofsky, H.; George, S.R.; O'dowd, B.F., 1995: Site-directed mutagenesis study of palmitoylation sites on dopamine D1 receptor. Society for Neuroscience Abstracts 21(1-3): 1119

Rabkova, L.M.; Anichkov, N.M., 1978: Significance of urinary infection for diagnosis clinical course and histological characteristics of epithelial tumors of the urinary bladder results of anti bacterial therapy. Examination of the case records and histological preparations of 1150 patients with epithelial tumors of the bladder revealed urine infection with inflammation in the bladder wall in 12.1% of the cases. The inflammation aggravated the clinical pro...

Vincenti, F.; Birbari, A.; Rizk, G., 1973: Renal vein renin in hypertension. Diagnostic and therapeutic implications. Le Journal Medical Libanais. Lebanese Medical Journal 26(1): 9-16

Zhang, S.; Yang, X.; Hu, F.; Wang, Q.; Fan, X.; Wang, J.; Gu, Y.; Wang, H.; Zhang, H.; Li, X., 2004: Clinical study of combined chemotherapy of domestic paclitaxel and vinorelbine plus platinum for advanced non-small cell lung cancer. To evaluate the efficacy and toxicity of combined chemotherapy of domestic paclitaxel and vinorelbine plus cisplatin and carboplatin in the treatment of advanced non-small cell lung cancer (NSCLC). A total of 181 initially treated patients with ad...

Shah, J.L.; Li, G.; Shaffer, J.L.; Azoulay, M.I.; Gibbs, I.C.; Nagpal, S.; Soltys, S.G., 2017: Stereotactic Radiosurgery and Hypofractionated Radiotherapy for Glioblastoma. Glioblastoma is the most common primary brain tumor in adults. Standard therapy depends on patient age and performance status but principally involves surgical resection followed by a 6-wk course of radiation therapy given concurrently with temozo...

Perez G., 1988: Transmissibility of hiv infection in chronic hemodialysis. Kidney International: 233

Graeber, C.; Berndt, H., 1999: Development of a new high temperature/high pressure flow system for the continuous digestion of biological samples. The development of a new high temperature/high pressure flow system that incorporates resistively heated capillaries for the continuous digestion of various samples is presented. The system allows the continuous digestion of samples at temperature...

Lu, K.V.; Jong, K.A.; Kim, G.Y.; Singh, J.; Dia, E.Q.; Yoshimoto, K.; Wang, M.Y.; Cloughesy, T.F.; Nelson, S.F.; Mischel, P.S., 2005: Differential induction of glioblastoma migration and growth by two forms of pleiotrophin. Glioblastoma is the most common malignant brain tumor of adults and one of the most lethal cancers. The secreted growth factor pleiotrophin (PTN) promotes glioblastoma migration and proliferation, initiating its oncogenic activities through two ce...

Tiu, C.; Terecoasa, E.; Grecu, N.; Nistor, R.; Frangu, S.; Antochi, F., 2017: Vertebral Artery Dissection: a Contemporary Perspective. Arterial dissections are among the most frequent causes of stroke in young adults. Usually they are associated with trauma, but as the modern imaging tools are evolving, more dissections are being diagnosed and more etiologies are being described....

Kaimori, Mitsuomi, 1994: Thyroglossal duct carcinoma in the lateral neck confirmed by immunohistological stain of thyroglobulin: Report of a case. Thyroglossal duct cyst and branchial cleft cyst are the two most common congenital cysts of the neck, and rarely show malignant change. The diagnosis is made based on the location of the cyst as well as the histological findings. We reported a thy...