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1 2 chloroethyl 3 cyclohexyl 1 nitroso urea chemo therapy of hemispheric supratentorial glio blastoma multiforme


, : 1 2 chloroethyl 3 cyclohexyl 1 nitroso urea chemo therapy of hemispheric supratentorial glio blastoma multiforme. Cancer 45(6): 1289-1299

Patients (103) with hemispheric supratentorial glioblastoma multiforme were studied. All patients were operated on and a histologic diagnosis of glioblastoma multiforme was made. Patients were randomly placed in 1 of the following 3 treatment schedules within 3 wk of surgery: group A, combined radiation therapy and CCNU (1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea) therapy (26 cases); group B, CCNU given orally every 6-8 wk (27 cases); group C, standard radiation therapy alone (50 cases).

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