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3 types of auer bodies in acute leukemia visualization of their protein by negative contrast after peroxidase cytochemistry

, : 3 types of auer bodies in acute leukemia visualization of their protein by negative contrast after peroxidase cytochemistry. Laboratory Investigation 41(5): 419-426

Ten cases of acute granulocytic leukemia with blast cells containing Auer bodies (AB) were studied by EM after cytochemical demonstration of myeloperoxidase. The cytochemical dense reaction product was used as a dark field to visualize unreactive protein of AB which may then be easily identified by its negative contrast. Three types of AB were identified which differ in their substructure. In type I, (5 patients with promyelocytic leukemia), all of the AB consisted of a hexagonal arrangement of hollow tubes. Cells from 4 cases of acute myeloblastic leukemia displayed type II AB, in which a unique pattern of protein associated in a regular linear arrangement with well defined periodicity was identified. Type III appeared characteristic of a subclass of acute myeloblastic leukemia in which large inclusions with Chediak-Higashi-like granules containing numerous micro-AB were seen. The configuration, size, and organization of the protein in the crystal were distinct from those seen in the 2 other types of AB. The nature of the protein in AB may be heterogeneous.


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