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A comparison of the antinociceptive and behavioral effects of d arginine substituted dipeptides and tetrapeptides in mice

, : A comparison of the antinociceptive and behavioral effects of d arginine substituted dipeptides and tetrapeptides in mice. Peptides (New York) 6(1): 35-40

Intracerebroventricular administration of D-Arg substituted dipeptides, H-Tyr-D-Arg-OMe and H-Tyr(Et)-D-Arg-OMe, and D-Arg2 substituted N-terminal tetrapeptides of dermorphin, H-Tyr-D-Arg-Phe-Gly-OEt and H-Tyr(Et)-D-Arg-Phe-Gly-OEt resulted in dose-related and naloxone-reversible antinociceptive effects. Tetrapeptides not only exhibited much more potent and prolonged activities than dipeptides but also were significantly antagonized even by a low dose of naloxone. Spontaneous motor activity was lowered by dipeptides throughout the observation period, which was scarcely antagonized by naloxone. Tetrapeptides elicited locomotor hyperactivity following an initial locomotor suppression. Only the locomotor hyperactivity was significantly antagonized by naloxone. Tetrapeptides may induce the effects via opioid receptors, whereas the effects of dipeptides are involved in various systems non-specifically.


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Lankhorst, P.P.; Smeets, J.W.H.; Haasnoot, C.A.G., 1995: Discrimination of the two diastereoisomeric glycosides heterodendrin and epi-heterodendrin by the combined use of NOE and molecular mechanics. The two glycosides (S)-heterodendrin and (R)-epi-heterodendrin were synthesized in a novel, one-step enzymatic synthesis, and separated by means of column chromatography. The 1H NMR spectra of the two diastereoisomers differ mainly in the chemical...

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Woodruff, J.D.; Erozan, Y.S.; Genadry, R., 1986: Adenocarcinoma arising in adenomyosis detected by atypical cytology. Adenocarcinoma in adenomyosis is unusual and in most cases is associated with adenocarcinoma in the surface endometrium. In the latter, the diagnosis is made in the removed specimen because of the finding of adenocarcinoma in curettings. In contra...

Bhattacharya S.K., 1984: Mechano physiology of dystrophic and normal mouse soleus and extensor digitorum longus corroborated with muscle calcium and magnesium contents. Federation Proceedings: Abstract 2822

Begu, D.C.; Pîrvănescu, A.; Begu, M.R.; Pîrvănescu, H., 1981: Surgical treatment of severe burns of the face and eyelids. Revista de Chirurgie, Oncologie, Radiologie, O. R. L., Oftalmologie, Stomatologie. Seria: Oftalmologie 25(1): 55-56

Wroblewski, J.; Engström, M.; Edwall-Arvidsson, C.; Sjöberg, G.; Sejersen, T.; Lendahl, U., 1997: Distribution of nestin in the developing mouse limb bud in vivo and in micro-mass cultures of cells isolated from limb buds. Early skeletal muscle development is accompanied by changes in the composition of the cytoskeleton. In this report we analyze the distribution of the intermediate filament nestin in the developing mouse limb buds in vivo and in mesenchymal cells i...

Matsuo M., 1970: Experimental lung transplantation effect of combined immuno suppressive procedures. Nagasaki Igakkai Zasshi 45(1): 1-21

Hood, Dave., 2002: Preliminary insect survey at Ngala. CCA Ecological Journal, 4: 127-128