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A correspondence of mouse organs and tissues to the central and peripheral compartments of the kinetic model that is based on the drug metabolite ratio in the blood plasma and other tissues


, : A correspondence of mouse organs and tissues to the central and peripheral compartments of the kinetic model that is based on the drug metabolite ratio in the blood plasma and other tissues. Farmakologiya i Toksikologiya (Moscow) 50(6): 65-68

The kinetic scheme of distribution of a structural analogue of phenazepam 7-brom-5-phenyl-1,2-dihdro-3H-1,4-benzdiazepine-2-on (I) and its main metabolites in the mouse body was presented. The process parameters were compared with the parameters of mouse body distribution of other N1-unsubstituted derivatives of 1,4-benzdiazepine.

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