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A new chromogenic assay for the specific determination of prothrombin

, : A new chromogenic assay for the specific determination of prothrombin. Journal of Clinical Pathology 32(7): 651-654

A new method for the specific assay of [human] prothrombin was described which utilizes Taipan snake [Oxvuranus scutellatus] venom and the chromogenic substrate Tos-Gly-Pro-Arg-pNA (Chromozym TH). The method was sensitive and reproducible and showed good correlation with a conventional specific assay for prothrombin. The reaction was dependent on Ca ions and phospholipid, and was sensitive to the coumarin-induced prothrombin defect. The assay was rapid and well suited for use in the routine coagulation laboratory.


PMID: 500835

DOI: 10.1136/jcp.32.7.651

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