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A role for mature B cells in bone marrow transplantation


, : A role for mature B cells in bone marrow transplantation. Immunology 64(1): 147-153

The proliferative potential of membrane Ig (mIg)-bearing B lymphocytes was assessed in an adoptive transfer system based on the use of non-inbred rabbits matched for major histocompatibility (MHC) antigens and mismatched for immunoglobulin (Ig) allotypes. Cell suspensions made from spleens (SP), mesenteric lymph nodes (LN), or bone marrow (BM) of allotype b4b5 rabbits were deprived of B cells with mIg of the b4 type by adherence to plastic dishes coated with affinity-purified anti-b4. When such b4-depleted cell populations were injected into newborn hosts of allotype b6b6, stable and lasting chimerism promptly resulted, in which donor-derived products were almost entirely of the b5 allotype. Chimeras formed by transfer of unfractionated cells from b4b5 donors, on the other hand, exhibited a predominance of the b4 allotype, as seen in the living donors. BM but not SP or LN contained precursors capable of differentiating into mIg+ lymphocytes in culture, but no evidence was obtained for engraftment and differentiation by such B-cell precursors or more primitive stem cells in vivo. These studies suggest a potentially significant role for mature B cells in reconstituting the immune system of human transplant recipients.

US$29.90

PMID: 3290093


Other references

Haun, F., 1981: Rare case of particularly extensive odontodysplasia (II). Die Quintessenz 32(4): 653-658

Chaturvedi, S.S., 2005: Monthly variation in plant biomass, net primary productivity and turnover of gangetic wasteland of varanasi. The present study was carried out to estimate monthly variation in plant biomass, net primary productivity and turnover at two wasteland sites on the bank of river Ganga at Varanasi. The maximum total above and belowground plant biomass were foun...

Naganathan, A.N.; Doshi, U.; Muñoz, V., 2007: Protein folding kinetics: barrier effects in chemical and thermal denaturation experiments. Recent experimental work on fast protein folding brings about an intriguing paradox. Microsecond-folding proteins are supposed to fold near or at the folding speed limit (downhill folding), but yet their folding behavior seems to comply with class...

Cherry L.M.; Wilson A.C., 1977: Comparison of morphological and biochemical change in the evolution of humans and chimpanzees. American Journal of Human Genetics 29(6): 31A

Russell, I.J.; Sellick, P.M., 1983: Low-frequency characteristics of intracellularly recorded receptor potentials in guinea-pig cochlear hair cells. Intracellular receptor potentials were recorded from inner and outer hair cells in response to low-frequency tones, from the basal, high-frequency region of the guinea-pig cochlea. The receptor potentials recorded from inner hair cells are asymmet...

Schoormans, D.; Sprangers, M.A.G.; van Melle, J.P.; Pieper, P.G.; van Dijk, A.P.J.; Sieswerda, G.T.J.; Hulsbergen-Zwarts, Mët.S.; Plokker, T.Hwm.; Brunninkhuis, L.G.H.; Vliegen, H.W.; Mulder, B.J.M., 2016: Clinical and psychological characteristics predict future healthcare use in adults with congenital heart disease. To deliver adequate care to patients with congenital heart disease (CHD), it is important to know which patients use what type of care. This knowledge is valuable, as modification of these factors may be used as means to regulate healthcare use. O...

Vuilleumier, Bs, 1971: Pleistocene changes in the fauna and flora of South America; present speciation patterns of the South American biota resulted from Pleistocene climatic changes. Science 173 (3999) 771-780

Reintam, L.; Leedu, A., 1994: Soil degradation induced by oil-shale mining. Soil degradation as a result of oil-shale mining in northeastern Estonia is discussed. Widespread subsidence was considered characteristic in these areas which are expanding due to the introduction of new technology. As a result of mining activiti...

Weybrew, J.A.; Mann, T.J., 1958: Some observations on the elaboration of plastid pig-ments in tobacco. Pigment analyses, by a spectro-photometric method, were made on 4 lines of tobacco[long dash]402, Ky 16, Consolation (402), Consolation (Ky 16)[long dash]at weekly intervals throughout the growing season. In 402 and Ky 16, pigment concentration, b...

Ishiguro, C.; Hall, M.; Neyarapally, G.A.; Dal Pan, G., 2013: Post-market drug safety evidence sources: an analysis of FDA drug safety communications. Pharmacoepidemiology and Drug Safety 21(10): 1134-1136