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A study of labeled pluronic f 68 poly oxalkal after intra venous injection into the dog


, : A study of labeled pluronic f 68 poly oxalkal after intra venous injection into the dog. Journal of Surgical Research 25(4): 349-356

3H-Labeled Pluronic F-68 [polyoxalkal] was given i.v. to dogs. The 3H-labeled Pluronic F-68 was measured in whole blood, plasma, plasma protein-free filtrate, washed and unwashed red blood cells, urine and lymph during the 25-h administration and in various organs at the end of 24 h. Approximately 75% of the detergent was transported in the plasma as free Pluronic F-68, and 25% appeared to be attached to albumin. At the end of 24 h, approximately 40% of the initial dose was excreted in the urine, and 3H-labeled Pluronic was found in all organs. Pluronic F-68 (polyoxalkal), a nonionic surface-active agent, has been used as a detergent for a variety of biological purposes including the stabilization of fat emulsions, reduction of blood viscosity, diminution of platelet adhesiveness [10, 2], and as a perfusion additive for extracorporeal circulation.

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